Placenta-Specific Protein 1 Is Conserved throughout the Placentalia under Purifying Selection

Table 1

Nonsynonymous (dN) and synonymous (dS) substitution ratios (dN/dS) for each of the four PLAC1 protein domains among four rodent and four carnivore species used in this study. A dN/dS < 1.00 is an indication of purifying selection. Species abbreviations are given in the text.

(a) Rodentia

	Signal peptide				Transmembrane				ZP3				C-terminal
	Mmu	Rno	Itr	Dor	Mmu	Rno	Itr	Dor	Mmu	Rno	Itr	Dor	Mmu	Rno	Itr	Dor
Mmu	—	0.24	0.38	0.47	—	0.11	0.01	0.00	—	0.11	0.08	0.09	—	0.13	0.61	0.66
Rno		—	0.45	0.55		—	0.00	0.00		—	0.09	0.10		—	0.08	0.80
Itr			—	0.32			—	0.00			—	0.07			—	0.82
Dor				—				—				—				—

(b) Carnivora

	Signal peptide				Transmembrane				ZP3				C-terminal
	Cfa	Fdo	Ame	Mpu	Cfa	Fdo	Ame	Mpu	Cfa	Fdo	Ame	Mpu	Cfa	Fdo	Ame	Mpu
Cfa	—	0.33	0.89	1.17	—	0.23	0.00	0.00	—	0.15	0.07	0.07	—	0.82	0.38	0.51
Fdo		—	99.0	0.73		—	0.12	0.00		—	0.10	0.13		—	0.37	0.48
Ame			—	1.73			—	0.00			—	0.11			—	0.50
Mpu				—				—				—				—