Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis
Table 2
Summary of ORs of the HSP70 polymorphism and cancer risk.
Variables
Dominant model
Recessive model
Ht versus WT Ho
VR Ho versus WT Ho
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
HSP70-2
Total
17
1.53 (1.11, 2.09)
<0.00001
81
1.91 (1.06, 3.45)
<0.00001
87
1.38 (1.03, 1.84)
<0.00001
74
2.34 (1.21, 4.54)
<0.00001
88
Ethnicity
Asian
7
1.96 (1.10, 3.51)
<0.00001
87
2.34 (0.94, 5.85)
<0.00001
86
1.67 (1.03, 2.71)
<0.0001
80
3.12 (0.99, 9.77)
<0.00001
89
European
4
1.06 (0.59, 1.89)
0.0009
82
0.59 (0.29, 1.22)
0.06
64
1.04 (0.54, 1.99)
0.007
80
0.61 (0.23, 1.66)
0.01
78
African
4
1.34 (1.00, 1.80)
0.19
37
7.06 (2.33, 21.41)
0.0009
82
1.09 (0.66, 1.82)
0.11
51
7.56 (2.44, 23.39)
0.005
77
Mixed
2
1.44 (0.45, 4.65)
0.03
79
0.53 (0.31, 0.91)
0.62
0
1.78 (0.55, 5.78)
0.03
78
0.77 (0.27, 2.23)
0.13
55
Cancer type
Hepatocellular
3
2.41 (1.50, 3.87)
0.06
65
4.98 (3.18, 7.79)
0.19
40
1.80 (1.34, 2.42)
0.38
0
6.07 (2.79, 13.19)
0.10
57
Breast
3
1.16 (0.81, 1.64)
0.29
19
3.61 (0.43, 30.28)
<0.00001
92
1.06 (0.55, 2.05)
0.07
62
3.86 (0.56, 26.43)
0.0002
88
Others
11
1.39 (0.93, 2.07)
<0.00001
82
1.13 (0.64, 2.00)
<0.00001
78
1.37 (0.92, 2.06)
<0.00001
78
1.43 (0.70, 2.93)
<0.00001
83
Source of control
PB
11
1.57 (1.06, 2.34)
<0.00001
81
2.69 (1.21, 5.97)
<0.00001
87
1.44 (0.95, 2.16)
<0.00001
78
3.27 (1.36, 7.83)
<0.00001
87
HB
6
1.46 (0.83, 2.57)
<0.00001
84
1.17 (0.44, 3.09)
<0.00001
90
1.31 (0.86, 2.00)
0.006
69
1.43 (0.46, 4.47)
<0.00001
90
HSP70-hom
Total
10
0.85 (0.53, 1.37)
<0.00001
87
1.05 (0.50, 2.18)
0.008
60
0.84 (0.55, 1.29)
<0.00001
83
0.98 (0.43, 2.24)
0.001
68
Ethnicity
Asian
4
0.55 (0.24, 1.28)
<0.00001
93
0.68 (0.14, 3.32)
0.001
81
0.59 (0.28, 1.23)
<0.00001
91
0.57 (0.09, 3.42)
0.0002
85
European
1
1.12 (0.71, 1.75)
NA
NA
1.31 (0.56, 3.03)
NA
NA
1.07 (0.66, 1.74)
NA
NA
1.34 (0.57, 3.13)
NA
NA
African
3
2.02 (0.41, 9.94)
<0.0001
90
3.03 (0.24, 38.65)
0.04
70
1.79 (0.44, 7.29)
0.0006
86
3.33 (0.20, 55.83)
0.02
75
Mixed
2
0.61 (0.22, 1.68)
0.11
61
0.63 (0.10, 3.88)
0.97
0
0.64 (0.23, 1.77)
0.11
61
0.59 (0.10, 3.64)
0.95
0
Source of control
PB
8
0.86 (0.49, 1.52)
<0.00001
89
0.87 (0.39, 1.94)
0.008
63
0.85 (0.51, 1.42)
<0.00001
85
0.79 (0.32, 1.98)
0.001
71
HB
2
0.78 (0.18, 3.50)
0.008
86
3.58 (0.99, 12.93)
0.26
23
0.77 (0.20, 2.97)
0.02
82
3.66 (1.03, 13.02)
0.19
42
HSP70-1
Total
5
1.30 (0.75, 2.24)
<0.00001
89
1.02 (0.52, 2.00)
0.0008
79
1.26 (0.75, 2.12)
<0.0001
86
1.13 (0.52, 2.45)
0.0001
83
: number of studies; aTest for heterogeneity. CI, confidence interval; OR, odds ratio; Ht + VR Ho versus WT Ho, dominant model; VR Ho versus Ht + WT Ho, recessive model; NA, not applicable.
