The Scientific World Journal / 2014 / Article / Tab 3 / Review Article
Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis Table 3 Pooled RR of acotiamide versus placebo for nonresponders by Mantel-Haenszel fixed-effect model.
Groups or subgroups Number of trials [reference] Number of patients RR; 95% CI value
Test of heterogeneity valueOverall symptoms 2 [16 ] 768 0.95; 0.73–1.24 0.710 0.510 0% 50 mg, tid 1 [16 ] 227 1.46; 0.78–2.73 0.230 NA NA 100 mg, tid 2 [16 ] 431 0.83; 0.55–1.26 0.380 0.420 0% 300 mg, tid 2 [16 ] 441 0.90; 0.60–1.34 0.590 0.590 0% PDS 2 [16 ] 396 0.71; 0.50–1.02 0.060 0.300 18% 50 mg, tid 1 [16 ] 151 1.22; 0.64–2.34 0.540 NA NA 100 mg, tid 2 [16 ] 206 0.51; 0.26–0.99 0.050 0.370 0% 300 mg, tid 2 [16 ] 218 0.61; 0.34–1.10 0.100 0.560 0% EPSa 2 [16 ] 320 1.76; 0.90–3.45 0.100 0.190 35% 50 mg, tid 1 [16 ] 73 3.89; 0.46–33.17 0.210 NA NA 100 mg, tid 2 [16 ] 184 1.91; 0.48–7.57 0.360 0.170 47% 300 mg, tid 2 [16 ] 192 2.31; 0.34–15.74 0.390 0.070 70%
a Mantel-Haenszel random-effects model. CI, confidential interval; FD, functional dyspepsia; NA, not applicable; RR, risk ratio; and tid, three times daily.