The Scientific World Journal / 2014 / Article / Tab 4

Review Article

Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis

Table 4

Pooled RR of adverse events in FD patients receiving acotiamide versus placebo by Mantel-Haenszel fixed-effect model.

GroupsNumber of trials [reference]Number of patientsRR; 95% CI value Test of heterogeneity
value

Serum prolactin increaseda4 [11, 16, 25]17091.59; 0.79–3.210.1900.12040%
Alanine aminotransferase increased4 [11, 16, 25]17091.42; 0.82–2.470.2100.7100%
Triglycerides increased3 [16, 25]16670.89; 0.69–1.140.3600.8100%
-glutamyltransferase increased3 [16, 25]16671.01; 0.66–1.540.9700.6300%
White blood cell count increased1 [25]8920.65; 0.34–1.270.210NANA
Serum bilirubin increased1 [25]8921.04; 0.55–1.950.910NANA
Constipation2 [16]7750.99; 0.34–2.920.9800.6200%
Diarrhoea3 [16, 25]16671.34; 0.81–2.230.2500.8600%
Nasopharyngitis1 [25]8920.93; 0.61–1.420.750NANA

aMantel-Haenszel random-effects model.
CI, confidential interval; FD, functional dyspepsia; NA, not applicable; and RR, risk ratio.