Classifying Lupus Nephritis: An Ongoing Story

Figure 4

Lupus nephritis class IV. (a) Class IV-S case with segmental endocapillary proliferation. The lesion was diffuse in the biopsy (not shown in the picture). (b) Global endocapillary proliferation with leukocyte infiltration. (c) Endocapillary proliferation with widespread wire loop appearance in the glomerular capillary wall indicator of subendothelial immune deposits by light microscopy. (d) Reflection of the subendothelial deposits as fuchsinophilic deposits in Masson Trichrome stain. (e) Global wire loop appearance without mesangial or endocapillary cellular proliferation. This finding was diffuse in the biopsy (not shown in the picture). (f) Significant immune deposit overload in glomerular capillary wall by IFM (×400).