A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations

Table 2

Zone of inhibition in mm at 25, 50, and 100 µg/mL concentrations.

Compd name	Antibacterial activity									Antifungal activity
	S.  aureus			E. coli			K. pneumoniae			C. tropicalis			C.  albicans
	25	50	100	25	50	100	25	50	100	25	50	100	25	50	100
3a	13	17	20	15	20	22	16	22	25	14	18	20	13	15	18
3b	14	16	20	16	19	24	15	21	24	15	17	21	14	17	19
3c	15	15	19	14	21	25	14	23	26	13	16	20	15	16	20
3d	11	12	17	12	15	16	09	14	15	10	12	15	10	12	14
3e	10	13	15	11	16	17	08	15	18	09	11	14	09	11	12
3f	09	12	16	09	14	16	09	13	14	09	12	13	09	10	10
3g	02	06	08	05	07	08	05	07	09	02	04	06	03	04	05
3h	03	04	09	03	05	07	04	08	10	01	03	05	03	06	09
3i	05	07	08	04	06	08	03	06	08	03	04	06	05	06	08
3j	14	18	21	18	18	23	15	21	23	15	18	21	13	15	17
3k	13	19	20	17	20	22	17	23	24	16	19	21	15	17	18
3l	12	18	21	16	19	25	16	22	26	12	15	21	13	16	19
3m	10	10	15	10	12	15	09	15	16	10	12	15	09	11	12
3n	08	11	14	08	13	14	10	13	18	09	11	14	09	09	11
3o	08	10	14	09	14	16	09	13	19	08	10	12	10	10	12
3p	03	04	09	04	05	08	06	08	12	04	06	08	03	05	07
3q	03	05	07	03	05	08	05	09	11	03	05	07	05	06	08
3r	04	06	08	06	08	09	04	08	10	02	05	06	03	06	07
3s	10	10	15	10	12	15	09	14	15	10	12	14	11	12	13
3t	09	11	13	11	14	17	10	15	18	08	11	15	09	10	12
3u	08	11	14	08	13	14	10	13	14	09	13	13	08	12	14
3v	09	09	16	10	12	15	11	12	17	10	12	15	09	13	15
3w	08	10	14	09	14	16	09	12	15	09	11	16	10	11	12
3x	09	12	12	09	11	14	08	14	16	08	10	17	09	10	12
3y	04	06	09	05	08	10	05	09	10	05	09	10	04	05	06
3z	05	05	08	04	09	11	04	10	12	04	08	11	04	04	05
Std.1	15	19	22	18	21	25	17	23	27	—	—	—	—	—	—
Std.2	—	—	—	—	—	—	—	—	—	15	19	22	16	19	21

Std.1: gentamycin, Std.2: fluconazole.
The bold font refers to the compounds which have shown more potent antimicrobial activities.