Research Article

Genome Wide Analysis of Sex Difference in Gene Expression Profiles of Bone Formations Using sfx Mice and BXD RI Strains

Figure 3

Gene network among bone relevant genes, which are upregulated in female while downregulated in male, constructed using expression profiles from spleen of male BXD mouse strains. (a) The 12 nodes in the graph below show the selected traits. All nodes are displayed. The 11 edges between the nodes, filtered from the 66 total edges and drawn as curves, show Pearson correlation coefficients greater than 0.35 or less than −0.35. The graph’s canvas is 40.0 by 40.0 cm and the node labels are drawn with a 14.0 point font and the edge labels are drawn with a 14.0 point font. (b) The 32 nodes in the graph below show the selected traits. All nodes are displayed. The 117 edges between the nodes, filtered from the 496 total edges and drawn as curves, show Pearson correlation coefficients greater than 0.4 or less than −0.4. The graph’s canvas is 40.0 by 40.0 cm and the node labels are drawn with a 14.0 point font and the edge labels are drawn with a 14.0 point font. (c) The 44 nodes in the graph below show the selected traits. All nodes are displayed. The 156 edges between the nodes, filtered from the 946 total edges and drawn as curves, show Pearson correlation coefficients greater than 0.4 or less than −0.4. The graph’s canvas is 40.0 by 40.0 cm and the node labels are drawn with a 14.0 point font and the edge labels are drawn with a 10.0 point font.
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(a)
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(b)
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(c)