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The Scientific World Journal
Volume 2014 (2014), Article ID 586510, 8 pages
http://dx.doi.org/10.1155/2014/586510
Review Article

Aspect of Thrombolytic Therapy: A Review

1Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh
2Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh

Received 10 May 2014; Accepted 16 November 2014; Published 10 December 2014

Academic Editor: Raul Moreno Gomez

Copyright © 2014 Md. Ramjan Ali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Thrombolytic therapy, also known as clot busting drug, is a breakthrough treatment which has saved untold lives. It has been used in the clinical area to treat venous and arterial thromboembolic complaints which are a foremost cause of death. In 1761, Morgagni lead the way of thrombolytic therapy. Now day’s different types of thrombolytic drugs are currently available in market: alteplase, anistreplase, urokinase, streptokinase, tenecteplase, and so forth. Thrombolytic therapy should be given with maintaining proper care in order to minimize the risk of clinically important bleeding as well as enhance the chances of successfully thrombolysis of clot. These cares include preinfusion care, during the infusion care, and postinfusion care. Besides proper knowledge of contraindication, evolutionary factor, and combination of drug is essential for successful thrombolytic therapy. In these review we discussed about these aspect of thrombolytic therapy.