Figure 2: Effects of pioglitazone on ACE2 mRNA expression in insulin-sensitive tissues in rats fed a high-fat diet. In liver and adipose tissue, ACE2 mRNA expression was significantly greater in the HP group compared with the HFD group. In skeletal muscle, ACE2 mRNA expression did not differ between the HFD and HP groups. NC, normal control; HFD, high-fat diet; PC, pioglitazone control; HP, high-fat diet plus pioglitazone.