Effects of Thapsigargin on the Proliferation and Survival of Human Rheumatoid Arthritis Synovial Cells
Figure 4
Thapsigargin inhibits cyclin D1 expression through mTOR pathway. (a) Western blots showing that the protein levels mTOR downstream markers pS6K and p4EBP1 were decreased in MH7A cells by thapsigargin treatment. (b) A scheme model highlighting that thapsigargin impairs cyclin D1 expressions by mTOR pathway and finally leads to disrupted cell proliferations and survivals in MH7A human rheumatoid arthritis synovial cells.
