Gastroprotective Activity of Violacein Isolated from <i>Chromobacterium violaceum</i> on Indomethacin-Induced Gastric Lesions in Rats: Investigation of Potential Mechanisms of Action

<table>Effect of COX-1 and COX-2 inhibitors and violacein (40 mg/kg, orally) on gastric microvascular permeability induced by indomethacin in rats. Values are mean ± SD (<i>n </i>= 6). <svg height="17.825001" id="M34" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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q0 -76 10 -138.5t37 -107.5t69 -45q32 0 55.5 25t35.5 68.5t17.5 91.5t5.5 105t-5.5 105.5t-18 92t-36 68t-56.5 24.5z" id="x30"></path></g><g transform="matrix(.017,-0,0,-.017,60.918,13.688)"><path d="M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8
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</svg> compare vehicle + Indo with all the groups; <svg height="19.65" id="M35" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 70.224998 19.65" width="70.224998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.017,-0,0,-.017,11.575,15.5)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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</svg> compare Vio (40 mg) + Indo with SC560 or Celecoxib + Vio (40 mg) + Indo. Indo: indomethacin; Vio: violacein.</table>

The Scientific World Journal

fig11

Figure 11

Figure 11: Gastroprotective Activity of Violacein Isolated from <i>Chromobacterium violaceum</i> on Indomethacin-Induced Gastric Lesions in Rats: Investigation of Potential Mechanisms of Action 

Figure 11 | Gastroprotective Activity of Violacein Isolated from Chromobacterium violaceum on Indomethacin-Induced Gastric Lesions in Rats: Investigation of Potential Mechanisms of Action 