Defining Biological Networks for Noise Buffering and Signaling Sensitivity Using Approximate Bayesian Computation
Figure 5
(a) In the yeast nitrogen catabolite repression system, the transcription factor Gat1p is activated in response to Gln3p. It can then activate its own transcription, as well as Dal80p, which binds to the same sequences as Gat1p and represses transcription. (b) Principal component analysis of the posterior distribution for model 6. PC1 is the first principal component, while PC8 describes the direction of least variance and therefore the most sensitive parameters. , , and are the degradation constants for components A, B, and C, respectively. indicates the eigenvalue of variance covariance matrix. (c) Parameter posterior distribution for Model 6. is the normalized degradation time scale for Da.
