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The Scientific World Journal
Volume 2014 (2014), Article ID 627673, 13 pages
http://dx.doi.org/10.1155/2014/627673
Review Article

Sodium Bicarbonate Therapy in Patients with Metabolic Acidosis

Nephrology Division, Hospital General Juan Cardona, Avenida Pardo Bazán, s/n, Ferrol, 15406 A Coruña, Spain

Received 30 July 2014; Revised 5 September 2014; Accepted 19 September 2014; Published 21 October 2014

Academic Editor: Biagio R. Di Iorio

Copyright © 2014 María M. Adeva-Andany et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. G. A. Aiken, “History of medical understanding and misunderstanding of acid base balance,” Journal of Clinical and Diagnostic Research, vol. 7, no. 9, pp. 2038–2041, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Berend, “Acid-base pathophysiology after 130 years: confusing, irrational and controversial,” Journal of Nephrology, vol. 26, no. 2, pp. 254–265, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. N. M. Nasir, P. Sthaneshwar, P. J. M. Yunus, and S.-F. Yap, “Comparing measured total carbon dioxide and calculated bicarbonate,” The Malaysian Journal of Pathology, vol. 32, no. 1, pp. 21–26, 2010. View at Google Scholar · View at Scopus
  4. W. S. Sly and P. Y. Hu, “Human carbonic anhydrases and carbonic anhydrase deficiencies,” Annual Review of Biochemistry, vol. 64, pp. 375–401, 1995. View at Publisher · View at Google Scholar · View at Scopus
  5. V. Kumar and B. S. Karon, “Comparison of measured and calculated bicarbonate values,” Clinical Chemistry, vol. 54, no. 9, pp. 1586–1587, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. J. B. Posner and F. Plum, “Spinal-fluid pH and neurologic symptoms in systemic acidosis,” The New England Journal of Medicine, vol. 277, no. 12, pp. 605–613, 1967. View at Publisher · View at Google Scholar · View at Scopus
  7. H. E. Cingolani, S. L. Faulkner, A. R. Mattiazzi, H. W. Bender, and T. P. Graham Jr., “Depression of human myocardial contractility with “respiratory” and “metabolic” acidosis,” Surgery, vol. 77, no. 3, pp. 427–432, 1975. View at Google Scholar · View at Scopus
  8. B. K. Gehlbach and G. A. Schimdt, “Bench-to-bedside review: treating acid-base abnormalities in the intensive care unit—the role of buffers,” Critical Care, vol. 8, no. 4, pp. 259–265, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Schotola, K. Toischer, A. F. Popov et al., “Mild metabolic acidosis impairs the β-adrenergic response in isolated human failing myocardium,” Critical Care, vol. 16, no. 4, article R153, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. S. M. Forsythe and G. A. Schmidt, “Sodium bicarbonate for the treatment of lactic acidosis,” Chest, vol. 117, no. 1, pp. 260–267, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. D. J. Cooper and L. I. G. Worthley, “Adverse haemodynamic effects of sodium bicarbonate in metabolic acidosis,” Intensive Care Medicine, vol. 13, no. 6, pp. 425–427, 1987. View at Publisher · View at Google Scholar · View at Scopus
  12. A. N. Ammari and K. F. Schulze, “Uses and abuses of sodium bicarbonate in the neonatal intensive care unit,” Current Opinion in Pediatrics, vol. 14, no. 2, pp. 151–156, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. J. L. Aschner and R. L.Poland, “Sodium bicarbonate: basically useless therapy,” Pediatrics, vol. 122, no. 4, pp. 831–835, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. R. F. Wilson, A. R. Spencer, J. G. Tyburski, H. Dolman, and L. H. Zimmerman, “Bicarbonate therapy in severely acidotic trauma patients increases mortality,” Journal of Trauma and Acute Care Surgery, vol. 74, no. 1, pp. 45–50, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. W. C. Waters III, J. D. Hall, and W. B. Schwartz, “Spontaneous lactic acidosis. The nature of the acid-base disturbance and considerations in diagnosis and management,” The American Journal of Medicine, vol. 35, no. 6, pp. 781–793, 1963. View at Publisher · View at Google Scholar · View at Scopus
  16. G. J. Roth and D. Porte Jr., “Chronic lactic acidosis and acute leukemia,” Archives of Internal Medicine, vol. 125, no. 2, pp. 317–321, 1970. View at Publisher · View at Google Scholar · View at Scopus
  17. R. A. Wainer, P. H. Wiernik, and W. L. Thompson, “Metabolic and therapeutic studies of a patient with acute leukemia and severe lactic acidosis of prolonged duration,” The American Journal of Medicine, vol. 55, no. 2, pp. 255–260, 1973. View at Publisher · View at Google Scholar · View at Scopus
  18. D. S. Fraley, S. Adler, F. J. Bruns, and B. Zett, “Stimulation of lactate production by administration of bicarbonate in a patient with a solid neoplasm and lactate acidosis,” The New England Journal of Medicine, vol. 303, no. 19, pp. 1100–1102, 1980. View at Publisher · View at Google Scholar · View at Scopus
  19. A. L. A. Fields, S. L. Wolman, and M. L. Halperin, “Chronic lactic acidosis in a patient with cancer: therapy and metabolic consequences,” Cancer, vol. 47, no. 8, pp. 2026–2029, 1981. View at Google Scholar · View at Scopus
  20. P. W. Stacpoole, E. M. Harman, S. H. Curry, T. G. Baumgartner, and R. I. Misbin, “Treatment of lactic acidosis with dichloroacetate,” The New England Journal of Medicine, vol. 309, no. 7, pp. 390–396, 1983. View at Publisher · View at Google Scholar · View at Scopus
  21. D. J. Cooper, K. R. Walley, B. R. Wiggs, and J. A. Russell, “Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. A prospective, controlled clinical study,” Annals of Internal Medicine, vol. 112, no. 7, pp. 492–498, 1990. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Mathieu, R. Neviere, V. Billard, M. Fleyfel, and F. Wattel, “Effects of bicarbonate therapy on hemodynamics and tissue oxygenation in patients with lactic acidosis: a prospective, controlled clinical study,” Critical Care Medicine, vol. 19, no. 11, pp. 1352–1356, 1991. View at Publisher · View at Google Scholar · View at Scopus
  23. J. P. Assal, T. T. Aoki, F. M. Manzano, and G. P. Kozak, “Metabolic effects of sodium bicarbonate in management of diabetic ketoacidosis,” Diabetes, vol. 23, no. 5, pp. 405–411, 1974. View at Google Scholar · View at Scopus
  24. J. A. Lutterman, A. A. J. Adriaansen, and A. van't Laar, “Treatment of severe diabetic ketoacidosis. A comparative study of two methods,” Diabetologia, vol. 17, no. 1, pp. 17–21, 1979. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Lever and J. B. Jaspan, “Sodium bicarbonate therapy in severe diabetic ketoacidosis,” The American Journal of Medicine, vol. 75, no. 2, pp. 263–268, 1983. View at Publisher · View at Google Scholar · View at Scopus
  26. P. J. Hale, J. Crase, and M. Nattrass, “Metabolic effects of bicarbonate in the treatment of diabetic ketoacidosis,” The British Medical Journal, vol. 289, no. 6451, pp. 1035–1038, 1984. View at Publisher · View at Google Scholar · View at Scopus
  27. L. R. Morris, M. B. Murphy, and A. E. Kitabchi, “Bicarbonate therapy in severe diabetic ketoacidosis,” Annals of Internal Medicine, vol. 105, no. 6, pp. 836–840, 1986. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Gamba, J. Oseguera, M. Castrejon, and F. J. Gomez-Perez, “Bicarbonate therapy in severe diabetic ketoacidosis. A double blind, randomized, placebo controlled trial,” Revista de Investigacion Clinica, vol. 43, no. 3, pp. 234–238, 1991. View at Google Scholar · View at Scopus
  29. S. M. Green, S. G. Rothrock, J. D. Ho et al., “Failure of adjunctive bicarbonate to improve outcome in severe pediatric diabetic ketoacidosis,” Annals of Emergency Medicine, vol. 31, no. 1, pp. 41–48, 1998. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Viallon, F. Zeni, P. Lafond et al., “Does bicarbonate therapy improve the management of severe diabetic ketoacidosis?” Critical Care Medicine, vol. 27, no. 12, pp. 2690–2693, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. K. A. Latif, A. X. Freire, A. E. Kitabchi, G. E. Umpierrez, and N. Qureshi, “The use of alkali therapy in severe diabetic ketoacidosis.,” Diabetes Care, vol. 25, no. 11, pp. 2113–2114, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. A. E. Kitabchi, G. E. Umpierrez, J. M. Miles, and J. N. Fisher, “Hyperglycemic crises in adult patients with diabetes,” Diabetes Care, vol. 32, no. 7, pp. 1335–1343, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. H. R. Chua, A. Schneider, and R. Bellomo, “Bicarbonate in diabetic ketoacidosis—a systematic review,” Annals of Intensive Care, vol. 1, p. 23, 2011. View at Google Scholar
  34. B. Duhon, R. L. Attridge, A. C. Franco-Martinez, P. R. Maxwell, and D. W. Hughes, “Intravenous sodium bicarbonate therapy in severely acidotic diabetic ketoacidosis,” Annals of Pharmacotherapy, vol. 47, no. 7-8, pp. 970–975, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. P. W. Stacpoole, D. S. Kerr, C. Barnes et al., “Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children,” Pediatrics, vol. 117, no. 5, pp. 1519–1531, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. D. Luft, R. M. Schmuelling, and M. Eggstein, “Lactic acidosis in biguanide-treated diabetics: a review of 330 cases,” Diabetologia, vol. 14, no. 2, pp. 75–87, 1978. View at Publisher · View at Google Scholar · View at Scopus
  37. H. J. Kim, Y. K. Son, and W. S. An, “Effect of sodium bicarbonate administration on mortality in patients with lactic acidosis: a retrospective analysis,” PLoS ONE, vol. 8, no. 6, Article ID e65283, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. A. A. El-Solh, P. Abou Jaoude, and J. Porhomayon, “Bicarbonate therapy in the treatment of septic shock: a second look,” Internal and Emergency Medicine, vol. 5, no. 4, pp. 341–347, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. Z. X. Fang, Y. F. Li, X. Q. Zhou et al., “Effects of resuscitation with crystalloid fluids on cardiac function in patients with severe sepsis,” BMC infectious diseases, vol. 8, article 50, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. J. H. Boyd and K. R. Walley, “Is there a role for sodium bicarbonate in treating lactic acidosis from shock?” Current Opinion in Critical Care, vol. 14, no. 4, pp. 379–383, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. N. H. Mark, J. M. Leung, A. I. Arieff et al., “Safety of low-dose intraoperative bicarbonate therapy: a prospective, double-blind, randomized study,” Critical Care Medicine, vol. 21, no. 5, pp. 659–665, 1993. View at Publisher · View at Google Scholar · View at Scopus
  42. J. Hewitt, M. Uniacke, N. K. Hansi, G. Venkat-Raman, and K. McCarthy, “Sodium bicarbonate supplements for treating acute kidney injury,” Cochrane Database of Systematic Reviews, vol. 6, Article ID CD009204, 2012. View at Google Scholar · View at Scopus
  43. “Kidney disease: improving Global Outcomes (KDIGO). Chronic kidney disease work group. KDIGO 2012 clinical practice guidelina for the evaluation and management of chronic kidney disease,” Kidney International Supplements, vol. 3, no. 4, 2013. View at Publisher · View at Google Scholar
  44. P. Roderick, N. S. Willis, S. Blakeley, C. Jones, and C. Tomson, “Correction of chronic metabolic acidosis for chronic kidney disease patients,” Cochrane Database of Systematic Reviews, vol. 24, no. 1, Article ID CD001890, 2007. View at Google Scholar · View at Scopus
  45. P. Susantitaphong, K. Sewaralthahab, E. M. Balk, B. L. Jaber, and N. E. Madias, “Short- and long-term effects of alkali therapy in chronic kidney disease: a systematic review,” American Journal of Nephrology, vol. 35, no. 6, pp. 540–547, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. J. A. Eustace, B. Astor, P. M. Muntner, T. A. Ikizler, and J. Coresh, “Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease,” Kidney International, vol. 65, no. 3, pp. 1031–1040, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. C.-Y. Hsu and G. M. Chertow, “Elevations of serum phosphorus and potassium in mild to moderate chronic renal insufficiency,” Nephrology Dialysis Transplantation, vol. 17, no. 8, pp. 1419–1425, 2002. View at Publisher · View at Google Scholar · View at Scopus
  48. O. Moranne, M. Froissart, J. Rossert et al., “Timing of onset of CKD-related metabolic complications,” Journal of the American Society of Nephrology, vol. 20, no. 1, pp. 164–171, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. R. Wallia, A. Greenberg, B. Piraino, R. Mitro, and J. B. Puschett, “Serum electrolyte patterns in end-stage renal disease,” American Journal of Kidney Diseases, vol. 8, no. 2, pp. 98–104, 1986. View at Publisher · View at Google Scholar · View at Scopus
  50. R. M. Hakim and J. M. Lazarus, “Biochemical parameters in chronic renal failure,” American Journal of Kidney Diseases, vol. 11, no. 3, pp. 238–247, 1988. View at Publisher · View at Google Scholar · View at Scopus
  51. M. Dobre, W. Yang, J. Chen et al., “Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: a report from the Chronic Renal Insufficiency Cohort (CRIC) study,” American Journal of Kidney Diseases, vol. 62, no. 4, pp. 670–678, 2013. View at Publisher · View at Google Scholar · View at Scopus
  52. B. Widmer, R. E. Gerhardt, J. T. Harrington, and J. J. Cohen, “Serum electrolyte and acid base composition. The influence of graded degrees of chronic renal failure,” Archives of Internal Medicine, vol. 139, no. 10, pp. 1099–1102, 1979. View at Publisher · View at Google Scholar · View at Scopus
  53. D. A. Story, A. Tosolini, R. Bellomo, M. Leblanc, L. Bragantini, and C. Ronco, “Plasma acid-base changes in chronic renal failure: a Stewart analysis,” International Journal of Artificial Organs, vol. 28, no. 10, pp. 961–965, 2005. View at Google Scholar · View at Scopus
  54. M. K. Abramowitz, T. H. Hostetter, and M. L. Melamed, “The serum anion gap is altered in early kidney disease and associates with mortality,” Kidney International, vol. 82, no. 6, pp. 701–709, 2012. View at Publisher · View at Google Scholar · View at Scopus
  55. N. G. de Santo, G. Capasso, G. Malnic, P. Anastasio, L. Spitali, and A. D'Angelo, “Effect of an acute oral protein load on renal acidification in healthy humans and in patients with chronic renal failure,” Journal of the American Society of Nephrology, vol. 8, no. 5, pp. 784–792, 1997. View at Google Scholar · View at Scopus
  56. J. P. Bosch, A. Saccaggi, A. Lauer, C. Ronco, M. Belledonne, and S. Glabman, “Renal functional reserve in humans. Effect of protein intake on glomerular filtration rate,” The American Journal of Medicine, vol. 75, no. 6, pp. 943–950, 1983. View at Publisher · View at Google Scholar · View at Scopus
  57. P. Kontessis, S. Jones, R. Dodds et al., “Renal, metabolic and hormonal responses to ingestion of animal and vegetable proteins,” Kidney International, vol. 38, no. 1, pp. 136–144, 1990. View at Publisher · View at Google Scholar · View at Scopus
  58. L. Azadbakht, S. Atabak, and A. Esmaillzadeh, “Soy protein intake, cardiorenal indices, and C-reactive protein in type 2 diabetes with nephropathy: a longitudinal randomized clinical trial,” Diabetes Care, vol. 31, no. 4, pp. 648–654, 2008. View at Publisher · View at Google Scholar · View at Scopus
  59. S. Berkemeyer, J. Vormann, A. L. B. Günther, R. Rylander, L. A. Frassetto, and T. Remer, “Renal net acid excretion capacity is comparable in prepubescence, adolescence, and young adulthood but falls with aging,” Journal of the American Geriatrics Society, vol. 56, no. 8, pp. 1442–1448, 2008. View at Publisher · View at Google Scholar · View at Scopus
  60. A. Amodu and M. K. Abramowitz, “Dietary acid, age, and serum bicarbonate levels among adults in the United States,” Clinical Journal of the American Society of Nephrology, vol. 8, no. 12, pp. 2034–2042, 2013. View at Publisher · View at Google Scholar · View at Scopus
  61. F. J. Gennari, V. L. Hood, T. Greene, X. Wang, and A. S. Levey, “Effect of dietary protein intake on serum total CO2 concentration in chronic kidney disease: modification of Diet in Renal Disease study findings,” Clinical journal of the American Society of Nephrology, vol. 1, no. 1, pp. 52–57, 2006. View at Publisher · View at Google Scholar · View at Scopus
  62. J. J. Scialla, L. J. Appel, B. C. Astor et al., “Estimated net endogenous acid production and serum bicarbonate in African Americans with chronic kidney disease,” Clinical Journal of the American Society of Nephrology, vol. 6, no. 7, pp. 1526–1532, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. E. van den Berg, M. F. Engberink, E. J. Brink et al., “Dietary acid load and metabolic acidosis in renal transplant recipients,” Clinical Journal of the American Society of Nephrology, vol. 7, no. 11, pp. 1811–1818, 2012. View at Publisher · View at Google Scholar · View at Scopus
  64. C. P. Kovesdy, J. E. Anderson, and K. Kalantar-Zadeh, “Association of serum bicarbonate levels with mortality in patients with non-dialysis-dependent CKD,” Nephrology Dialysis Transplantation, vol. 24, no. 4, pp. 1232–1237, 2009. View at Publisher · View at Google Scholar · View at Scopus
  65. C. P. Kovesdy, “Metabolic acidosis and kidney disease: does bicarbonate therapy slow the progression of CKD?” Nephrology Dialysis Transplantation, vol. 27, no. 8, pp. 3056–3062, 2012. View at Publisher · View at Google Scholar · View at Scopus
  66. W. Chen and M. K. Abramowitz, “Metabolic acidosis and the progression of chronic kidney disease,” BMC Nephrology, vol. 15, no. 1, article 55, 2014. View at Publisher · View at Google Scholar · View at Scopus
  67. S. N. Shah, M. Abramowitz, T. H. Hostetter, and M. L. Melamed, “Serum bicarbonate levels and the progression of kidney disease: a cohort study,” American Journal of Kidney Diseases, vol. 54, no. 2, pp. 270–277, 2009. View at Publisher · View at Google Scholar · View at Scopus
  68. K. L. Raphael, G. Wei, B. C. Baird, T. Greene, and S. Beddhu, “Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans,” Kidney International, vol. 79, no. 3, pp. 356–362, 2011. View at Publisher · View at Google Scholar · View at Scopus
  69. J. J. Scialla, L. J. Appel, B. C. Astor et al., “Net endogenous acid production is associated with a faster decline in GFR in African Americans,” Kidney International, vol. 82, no. 1, pp. 106–112, 2012. View at Publisher · View at Google Scholar · View at Scopus
  70. E. Kanda, M. Ai, M. Yoshida, R. Kuriyama, and T. Shiigai, “High serum bicarbonate level within the normal range prevents the progression of chronic kidney disease in elderly chronic kidney disease patients,” BMC Nephrology, vol. 14, no. 1, article 4, 2013. View at Publisher · View at Google Scholar · View at Scopus
  71. L. Goldenstein, T. H. Driver, L. F. Fried, D. E. Rifkin, K. V. Patel, and R. H. Yenchek, “Serum bicarbonate concentrations and kidney disease progression in community-living elders: the health, aging, and body composition (Health ABC) study,” American Journal of Kidney Diseases, 2014. View at Publisher · View at Google Scholar
  72. T. H. Driver, M. G. Shlipak, R. Katz et al., “Low serum bicarbonate and kidney function decline: the Multi-Ethnic Study of Atherosclerosis (MESA),” American Journal of Kidney Diseases, 2014. View at Publisher · View at Google Scholar
  73. I. de Brito-Ashurst, M. Varagunam, M. J. Raftery, and M. M. Yaqoob, “Bicarbonate supplementation slows progression of CKD and improves nutritional status,” Journal of the American Society of Nephrology, vol. 20, no. 9, pp. 2075–2084, 2009. View at Publisher · View at Google Scholar · View at Scopus
  74. C. P. Kovesdy and K. Kalantar-Zadeh, “Oral bicarbonate: renoprotective in CKD?” Nature Reviews Nephrology, vol. 6, no. 1, pp. 15–17, 2010. View at Publisher · View at Google Scholar · View at Scopus
  75. S. Phisitkul, A. Khanna, J. Simoni et al., “Amelioration of metabolic acidosis in patients with low GFR reduced kidney endothelin production and kidney injury, and better preserved GFR,” Kidney International, vol. 77, no. 7, pp. 617–623, 2010. View at Publisher · View at Google Scholar · View at Scopus
  76. A. Mahajan, J. Simoni, S. J. Sheather, K. R. Broglio, M. H. Rajab, and D. E. Wesson, “Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy,” Kidney International, vol. 78, no. 3, pp. 303–309, 2010. View at Publisher · View at Google Scholar · View at Scopus
  77. N. Goraya, J. Simoni, C. Jo, and D. E. Wesson, “Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy,” Kidney International, vol. 81, no. 1, pp. 86–93, 2012. View at Publisher · View at Google Scholar · View at Scopus
  78. B. di Iorio, F. Aucella, G. Conte, A. Cupisti, and D. Santoro, “A prospective, multicenter, randomized, controlled study: the correction of metabolic acidosis with use of bicarbonate in Chronic Renal Insufficiency (UBI) Study,” Journal of Nephrology, vol. 25, no. 3, pp. 437–440, 2012. View at Publisher · View at Google Scholar · View at Scopus
  79. M. Gaggl, D. Cejka, M. Plischke et al., “Effect of oral sodium bicarbonate supplementation on progression of chronic kidney disease in patients with chronic metabolic acidosis: study protocol for a randomized controlled trial (SoBic-Study),” Trials, vol. 14, no. 1, article 196, 2013. View at Publisher · View at Google Scholar · View at Scopus
  80. Alkali Therapy in Chronic Kidney Disease, 2014.
  81. A. B. Libório, E. F. Daher, and M. C. M. de Castro, “Characterization of acid-base status in maintenance hemodialysis: physicochemical approach,” Journal of Artificial Organs, vol. 11, no. 3, pp. 156–159, 2008. View at Publisher · View at Google Scholar · View at Scopus
  82. F. O. Marques, A. B. Liborio, and E. F. Daher, “Effect of chloride dialysate concentration on metabolic acidosis in maintenance hemodialysis patients,” Brazilian Journal of Medical and Biological Research, vol. 43, no. 10, pp. 996–1000, 2010. View at Publisher · View at Google Scholar · View at Scopus
  83. F. Tentori, A. Karaboyas, B. M. Robinson et al., “Association of dialysate bicarbonate concentration with mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS),” American Journal of Kidney Diseases, vol. 62, no. 4, pp. 738–746, 2013. View at Publisher · View at Google Scholar · View at Scopus
  84. L. Gabutti, N. Ferrari, G. Giudici, G. Mombelli, and C. Marone, “Unexpected haemodynamic instability associated with standard bicarbonate haemodialysis,” Nephrology Dialysis Transplantation, vol. 18, no. 11, pp. 2369–2376, 2003. View at Publisher · View at Google Scholar · View at Scopus
  85. J. Uribarri, N. W. Levin, J. Delmez et al., “Association of acidosis and nutritional parameters in hemodialysis patients,” The American Journal of Kidney Diseases, vol. 34, no. 3, pp. 493–499, 1999. View at Publisher · View at Google Scholar · View at Scopus
  86. J. Bommer, F. Locatelli, S. Satayathum et al., “Association of predialysis serum bicarbonate levels with risk of mortality and hospitalization in the Dialysis Outcomes and Practice Patterns Study (DOPPS),” American Journal of Kidney Diseases, vol. 44, no. 4, pp. 661–671, 2004. View at Publisher · View at Google Scholar · View at Scopus
  87. S.-H. Lin, Y.-F. Lin, H.-M. Chin, and C.-C. Wu, “Must metabolic acidosis be associated with malnutrition in haemodialysed patients?” Nephrology Dialysis Transplantation, vol. 17, no. 11, pp. 2006–2010, 2002. View at Publisher · View at Google Scholar · View at Scopus
  88. D. Y. Wu, C. S. Shinaberger, D. L. Regidor, C. J. McAllister, J. D. Kopple, and K. Kalantar-Zadeh, “Association between serum bicarbonate and death in hemodialysis patients: is it better to be acidotic or alkalotic?” Clinical Journal of the American Society of Nephrology, vol. 1, no. 1, pp. 70–78, 2006. View at Publisher · View at Google Scholar · View at Scopus
  89. E. G. Lowrie and N. L. Lew, “Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities,” American Journal of Kidney Diseases, vol. 15, no. 5, pp. 458–482, 1990. View at Publisher · View at Google Scholar · View at Scopus
  90. Y. W. Chiu, J. D. Kopple, and R. Mehrotra, “Correction of metabolic acidosis to ameliorate wasting in chronic kidney disease: goals and strategies,” Seminars in Nephrology, vol. 29, no. 1, pp. 67–74, 2009. View at Publisher · View at Google Scholar · View at Scopus
  91. Fresenius Medical Care North America Medical Office, Dialysate Bicarbonate, 2012, http://www.renalweb.com/writings/alkalosis/FMC%20Jul%2025%202012.pdf.
  92. http://www.fda.gov/MedWatch/report.htm, http://fda.gov/MedicalDevices/Safety/AlertsandNotices/ucm305477.htm.
  93. S. A. Al-Abri and T. Kearney, “Baking soda misuse as a home remedy: case experience of the California Poison Control System,” Journal of Clinical Pharmacy and Therapeutics, vol. 39, no. 1, pp. 73–77, 2014. View at Publisher · View at Google Scholar · View at Scopus
  94. F. C. Husted, K. D. Nolph, and J. F. Maher, “NaHCO3 and NaC1 tolerance in chronic renal failure,” The Journal of Clinical Investigation, vol. 56, no. 2, pp. 414–419, 1975. View at Publisher · View at Google Scholar · View at Scopus
  95. N. G. Soler, M. A. Bennett, K. Dixon, M. G. FitzGerald, and J. M. Malins, “Potassium balance during treatment of diabetic ketoacidosis with special reference to the use of bicarbonate,” The Lancet, vol. 2, no. 7779, pp. 665–667, 1972. View at Google Scholar · View at Scopus
  96. W. S. Hughes, G. D. Aurbach, M. E. Sharp, and S. J. Marx, “The effect of the bicarbonate anion on serum ionized calcium concentration in vitro,” Journal of Laboratory and Clinical Medicine, vol. 103, no. 1, pp. 93–103, 1984. View at Google Scholar · View at Scopus
  97. R. B. Singer, R. C. Deering, and J. K. Clark, “The acute effects in man of a rapid intravenous infusion of hypertonic sodium bicarbonate solution. II. Changes in respiration and output of carbon dioxide,” The Journal of Clinical Investigation, vol. 35, no. 2, pp. 245–253, 1956. View at Publisher · View at Google Scholar
  98. R. E. J. Ryder, “Lactic acidosis: high-dose or low-dose bicarbonate therapy,” Diabetes Care, vol. 7, no. 1, pp. 99–102, 1984. View at Google Scholar · View at Scopus
  99. R. M. Bersin, K. Chatterjee, and A. I. Arieff, “Metabolic and hemodynamic consequences of sodium bicarbonate administration in patients with heart disease,” The American Journal of Medicine, vol. 87, no. 1, pp. 7–14, 1989. View at Publisher · View at Google Scholar · View at Scopus
  100. B. J. Hindman, “Sodium bicarbonate in the treatment of subtypes of acute lactic acidosis: physiologic considerations,” Anesthesiology, vol. 72, no. 6, pp. 1064–1076, 1990. View at Publisher · View at Google Scholar · View at Scopus
  101. K. Nakashima, T. Yamashita, S. Kashiwagi, N. Nakayama, T. Kitahara, and H. Ito, “The effect of sodium bicarbonate on CBF and intracellular pH in man: stable Xe-CT and 31P-MRS,” Acta Neurologica Scandinavica, vol. 93, supplement s166, pp. 96–98, 1996. View at Publisher · View at Google Scholar · View at Scopus
  102. T. Symreng, M. J. Flanigan, and V. S. Lim, “Ventilatory and metabolic changes during high efficiency hemodialysis,” Kidney International, vol. 41, no. 4, pp. 1064–1069, 1992. View at Publisher · View at Google Scholar · View at Scopus
  103. K. I. Sombolos, G. I. Bamichas, F. N. Christidou et al., “pO2 and pCO2 increment in post-dialyzer blood: the role of dialysate,” Artificial Organs, vol. 29, no. 11, pp. 892–898, 2005. View at Publisher · View at Google Scholar · View at Scopus
  104. M. Alfakir, M. Q. Moammar, M. I. Ali et al., “Pulmonary gas exchange during hemodialysis: a comparison of subjects with and without COPD on bicarbonate hemodialysis,” Annals of Clinical and Laboratory Science, vol. 41, no. 4, pp. 315–320, 2011. View at Google Scholar · View at Scopus
  105. G. Graziani, S. Casati, P. Passerini, M. Crepaldi, M. Campise, and G. Ambroso, “Pathophysiology and clinical consequences of metabolic alkalosis in hemodialyzed patients,” Archivio Italiano di Urologia Nefrologia Andrologia, vol. 59, no. 2, pp. 105–111, 1987. View at Google Scholar · View at Scopus
  106. B. Di Iorio, S. Torraca, C. Piscopo et al., “Dialysate bath and QTc interval in patients on chronic maintenance hemodialysis: pilot study of single dialysis effects,” Journal of Nephrology, vol. 25, no. 5, pp. 653–660, 2012. View at Publisher · View at Google Scholar · View at Scopus
  107. W. G. Goodman and G. London, “Vascular calcification in chronic kidney disease,” The American Journal of Kidney Diseases, vol. 43, no. 3, pp. 572–579, 2004. View at Publisher · View at Google Scholar · View at Scopus
  108. E. Klein, R. A. Ward, and G. B. Harding, “Calcium carbonate precipitation in bicarbonate hemodialysis,” Artificial Organs, vol. 10, no. 3, pp. 248–250, 1986. View at Publisher · View at Google Scholar · View at Scopus
  109. W. F. Neuman, P. E. Morrow, T. Y. Toribara, L. J. Casarett, B. J. Mulryan, and H. C. Hodge, “Evidence for complex ion formation in the calcium-bicarbonate system,” The Journal of Biological Chemistry, vol. 219, no. 2, pp. 551–555, 1956. View at Google Scholar · View at Scopus
  110. K. O. Pedersen, “The effect of bicarbonate, PCO2 and pH on serum calcium fractions,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 27, pp. 145–150, 1971. View at Google Scholar
  111. X. Chang, Y. Zheng, Q. Yang et al., “Carbonic anhydrase I (CA1) is involved in the process of bone formation and is susceptible to ankylosing spondylitis,” Arthritis Research and Therapy, vol. 14, no. 4, article R176, 2012. View at Publisher · View at Google Scholar · View at Scopus
  112. W. E. G. Müller, H. C. Schröder, U. Schlossmacher, V. A. Grebenjuk, H. Ushijima, and X. Wang, “Induction of carbonic anhydrase in SaOS-2 cells, exposed to bicarbonate and consequences for calcium phosphate crystal formation,” Biomaterials, vol. 34, no. 34, pp. 8671–8680, 2013. View at Publisher · View at Google Scholar · View at Scopus
  113. N. G. Soler, M. A. Bennett, M. G. FitzGerald, and J. M. Malins, “Successful resuscitation in diabetic ketoacidosis: a strong case for the use of bicarbonate,” Postgraduate Medical Journal, vol. 50, no. 585, pp. 465–468, 1974. View at Publisher · View at Google Scholar · View at Scopus
  114. P. Munk, M. H. Freedman, H. Levison, and R. M. Ehrlich, “Effect of bicarbonate on oxygen transport in juvenile diabetic ketoacidosis,” Journal of Pediatrics, vol. 84, no. 4, pp. 510–514, 1974. View at Publisher · View at Google Scholar · View at Scopus
  115. J. M. Ritter, H. S. Doktor, and N. Benjamin, “Paradoxial effect of bicarbonate on cytoplasmic pH,” The Lancet, vol. 335, no. 8700, pp. 1243–1246, 1990. View at Publisher · View at Google Scholar · View at Scopus
  116. D. J. A. Goldsmith, L. G. Forni, and P. J. Hilton, “Bicarbonate therapy and intracellular acidosis,” Clinical Science, vol. 93, no. 6, pp. 593–598, 1997. View at Google Scholar · View at Scopus
  117. J. A. Mattar, M. H. Weil, H. Shubin, and L. Stein, “Cardiac arrest in the critically ill. II. Hyperosmolal states following cardiac arrest,” The American Journal of Medicine, vol. 56, no. 2, pp. 162–168, 1974. View at Publisher · View at Google Scholar · View at Scopus
  118. C. Pichette, M. Bercovici, M. Goldstein, B. Stinebaugh, S. C. Tam, and M. Halperin, “Elevation of the blood lactate concentration by alkali therapy without requiring additional lactic acid accumulation: theoretical considerations,” Critical Care Medicine, vol. 10, no. 5, pp. 323–326, 1982. View at Publisher · View at Google Scholar · View at Scopus
  119. F. C. Luft, M. B. Zemel, J. A. Sowers, and N. S. M. H. F. Weinberger, “Sodium bicarbonate and sodium chloride: effects on blood pressure and electrolyte homeostasis in normal and hypertensive man,” Journal of Hypertension, vol. 8, no. 7, pp. 663–670, 1990. View at Publisher · View at Google Scholar · View at Scopus