Review Article
Sodium Bicarbonate Therapy in Patients with Metabolic Acidosis
Table 3
Influence of sodium bicarbonate therapy on chronic kidney disease progression.
| Type of study | Patients number | Main finding | Limitations | Reference |
| Randomized, single center | 134 | Patients supplemented with oral sodium bicarbonate are less likely to experience rapid progression of kidney disease. | Serum bicarbonate level in participants was 16 to 20 mM, limiting external validity. | de Brito-Ashurst et al., 2009 [73] | Prospective | 59 | The rate of estimated glomerular filtration rate (eGFR) decline was slower in patients who received sodium citrate. | The control group was composed of patients that were unable to take the medication. | Phisitkul et al., 2010 [75] | Prospective, randomized, controlled | 120 | The rate of cystatin C-eGFR decline is slower in patients given sodium bicarbonate. | The reduction in the rate of progression is not observed using other estimates of kidney function. | Mahajan et al., 2010 [76] |
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