Sodium Bicarbonate Therapy in Patients with Metabolic Acidosis

Table 4

Side effects of sodium bicarbonate therapy.

Side effects of sodium bicarbonate therapy
Hypokalemia
Ionized hypocalcemia
Prolongation of the QTc interval
Hypercapnia
Hemodynamic instability during hemodialysis
Increase in urinary sodium excretion
Potential progression of vascular calcifications
Side effects of sodium bicarbonate with uncertain clinical significance
(i) Impairment of tissue oxygenation
(ii) Intracellular acidosis
(iii) Paradoxical cerebrospinal fluid acidosis
(iv) Hyperosmolar state
(v) Increased lactate production
(vi) Slight blood pressure reduction