Facile and Promising Method for Michael Addition of Indole and Pyrrole to Electron-Deficient trans-β-Nitroolefins Catalyzed by a Hydrogen Bond Donor Catalyst Feist’s Acid and Preliminary Study of Antimicrobial Activity

Table 3

Feist’s acid catalysis substrate scope^a, pyrrole 5.

No.	Nitroolefin (2a–i)	Time (h)	Products	Product ID	Yield^b (%)
1		50		8a	81
				9a	13
2		24		8b	51
				9b	21
3		44		8c	84
				9c	14
4		20		8d	65
				9d	11
5		20		8e	48
6		20		8f	99
7		20		8g	99
8		44		8h	90
				9h	09
9		44		8i	18

aThe reactions were performed on 0.86 mmol scale; ^bthe isolated yield after column purification.