Research Article
Clinical and Renal Biopsy Findings Predicting Outcome in Renal Thrombotic Microangiopathy: A Large Cohort Study from a Single Institute in China
Table 6
Comparisons of clinical, laboratory, and renal pathological data among patients with aHUS, pregnancy-associated TMA, and malignant hypertension.
| | | aHUS | Pregnancy associated TMA | Malignant hypertension | P value |
| | Number of patients | 7 | 14 | 61 | |
| | Age (years) | | | | 0.122 | | Gender (male : female) | 5 : 2 | 0 : 14 | 55 : 6 | <0.001 | | Fever (%) | 0 | 2 (14.3) | 5 (8.2) | 0.534 | | Neurological abnormalities (%) | 1 (14.3) | 1 (7.1) | 2 (3.3) | 0.401 | | Liver involvement (%) | 0 | 7 (50) | 0 | <0.001 | | Heart involvement (%) | 0 | 0 | 1 (1.6) | 0.840 | | Hematuria (%) | 5 (71.4) | 10 (71.4) | 37 (60.7) | 0.677 | | Proteinuria (g/d) | | | | 0.816 | | Albumin (g/L) | | | | 0.239 | | Creatinine (mol/L) | 870.0 (671.0–1200) | 370.5 (78.5–602.8) | 560.0 (291.6–904.9) | 0.021 | | Hemoglobin (g/L) | | | | 0.037 | | Platelet count (/L) | | | | 0.004 | | Lactate dehydrogenase (IU/L) | 551 (266–1360) | 1156 (369–2762) | 216 (163–309) | <0.001 | | Modified Rose score | | | | 0.001 | | Acute renal TMA pathologic changes (%) | 5 (71.4) | 4 (28.6) | 7 (11.5) | <0.001 | | Chronic renal TMA pathologic changes (%) | 5 (71.4) | 2 (14.3) | 58 (95.1) | <0.001 | | Location of renal TMA pathologic changes | | | | | | G (%) | 0 | 4 (28.6) | 0 | <0.001 | | A (%) | 2 (28.6) | 4 (28.6) | 60 (98.4) | | G and A (%) | 5 (71.4) | 6 (42.9) | 1 (1.6) |
|
|
Notes: aHUS: atypical hemolytic uremic syndrome; G: glomeruli; A; artery/arteriole; G and A: glomeruli and artery/arteriole.
|
