Myotubularin-Related Phosphatase 3 Promotes Growth of Colorectal Cancer Cells
Figure 4
Knockdown of MTMR3 induces cell apoptosis via activation of Bad and PARP signaling pathways. (a) Cell apoptosis of HCT116 cells with two treatments (Lv-shMTMR3 and Lv-shCon) analyzed by flow cytometry using Annexin V/7-AAD double staining. The experiment was performed in triplicate and repeated three times. (b) The proportions of HCT116 cells corresponding to viable (Annexin V−/7-AAD−), necrotic (Annexin V−/7-AAD+), early (Annexin V+/7-AAD−), and late (Annexin V+/7-AAD+) apoptotic cells. (c) Activation of Bad and PARP signaling pathways measured by Intracellular Signaling Array. (, ).
