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The Scientific World Journal
Volume 2014, Article ID 703804, 8 pages
Research Article

Myotubularin-Related Phosphatase 3 Promotes Growth of Colorectal Cancer Cells

1Department of Colorectal Surgery, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang 310014, China
2Department of Gastroenterological Surgery, Zhejiang Provincial People’s Hospital, 158 Shangtang Road, Hangzhou, Zhejiang 310014, China

Received 18 March 2014; Revised 14 July 2014; Accepted 26 July 2014; Published 19 August 2014

Academic Editor: Toshimi Chiba

Copyright © 2014 Bo’an Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Response: Furthermore, we verified our results in another CRC cell line SW1116. Lv-shMTMR3 also efficiently transduced into SW1116 cells, as revealed by RFP fluorescence in Supplementary Figure S1a. The expression of MTMR3 was obviously decreased in SW1116 cells after Lv-shMTMR3 infection (Supplementary Figure S1b). The proliferation rate of SW1116 cells was also markedly decreased by MTMR3 knockdown (Supplementary Figure S1c). Taken together, these results indicated that knockdown of MTMR3 could significantly inhibit CRC cell proliferation.

  1. Supplementary Material