Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats

Table 2

Effects of combination treatments of diclofenac and the test antioxidants on paw thickness increase after 3 hr in a rat carrageenan-induced paw edema model.

Groups	Paw edema (thickness increase [cm] after 3 hr)	Inhibition %
Carrageenan (50 𝜇L of 1% solution)	0.26±0.06
Diclofenac (5 mg/kg, per os)	0.16±0.001^#	38%
Diclofenac + 𝛼-LA (50 mg/kg, IP)	0.21±0.001^#a	19%
Diclofenac + Se (2.5 mg/kg, po)	0.19±0.03^#a	27%
Diclofenac + Vit C (1 g/kg, per os)	0.18±0.01^#a	31%
Diclofenac + Vit E (300 mg/kg, po)	0.19±0.04^#a	27%
Diclofenac + Zn (25 mg/kg, po)	0.14±0.001^#a	46%

Values are means of 8 rats (±SD).
#Value is significantly different from carrageenan control (𝑃<0.05).
aValue is significantly different from diclofenac group (𝑃<0.05).