The Scientific World Journal / 2014 / Article / Tab 2

Research Article

Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats

Table 2

Effects of combination treatments of diclofenac and the test antioxidants on paw thickness increase after 3 hr in a rat carrageenan-induced paw edema model.

Groups Paw edema (thickness increase cm after 3 hr)Inhibition %

Carrageenan (50  L of 1% solution)

Diclofenac (5 mg/kg, per os) 38%

Diclofenac + -LA (50 mg/kg, IP) 19%

Diclofenac + Se (2.5 mg/kg, po) 27%

Diclofenac + Vit C (1 g/kg, per os) 31%

Diclofenac + Vit E (300 mg/kg, po) 27%

Diclofenac + Zn (25 mg/kg, po) 46%

Values are means of 8 rats (±SD).
Value is significantly different from carrageenan control ( ).
Value is significantly different from diclofenac group ( ).