The Scientific World Journal / 2014 / Article / Tab 4

Research Article

Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats

Table 4

Effects of combination treatments of diclofenac and the test antioxidants on plasma levels of MDA, hemolysate GSH, and erythrocyte SOD activity in a rat carrageenan-induced paw edema model.

GroupsMDA (nmol/mL)GSH (mg %)SOD (U/g Hb)

Normal (0.05 mL, 1% saline)
Carrageenan (50  L of 1% solution)
Diclofenac (5 mg/kg, po)
Diclofenac + -LA (50 mg/kg, IP)
Diclofenac + Se (2.5 mg/kg, po)
Diclofenac + Vit C (1 g/kg, po)
Diclofenac + Vit E (300 mg/kg, po)
Diclofenac + Zn (25 mg/kg, po)

Values are means of 8 rats (±SD).
Value is significantly different from normal control ( ).
Value is significantly different from carrageenan control ( ).
Value is significantly different from diclofenac group ( ).