Anticancer and Antitumor Potential of Fucoidan and Fucoxanthin, Two Main Metabolites Isolated from Brown Algae

Table 2

Anticancer and antitumor activity of fucoxanthin and its metabolites isolated from brown algae.

Type	Source	Type of activity	References
Fucoxanthin	U. pinnatifida	Inhibitory effect against growth of GOTO cells, a human neuroblastoma cell line	[46]
Fucoxanthin	U. pinnatifida	Inhibitory effect against duodenal carcinogenesis induced by N-ethyl-N′-nitro-N-nitrosoguanidine in mice	[47]
Fucoxanthin	U. pinnatifida	Suppression of skin and liver carcinogenesis in vivo	[48]
Fucoxanthin	H. fusiforme	Reduced development of putative preneoplastic aberrant crypt foci (ACF) in colon of mice	[49]
Fucoxanthin	U. pinnatifida	Inhibitory effect against the proliferation of HL-60, human leukemia cell line, through apoptosis	[50]
Fucoxanthin	U. pinnatifida	Decreased cell viability in prostate cancer cell lines of PC-3, DU 145, and LNCaP	[51]
Fucoxanthin	U. pinnatifida	Inhibitory effect against viability of human colon cancer cell lines, HT-29, DLD-1, and Caco-2, through apoptosis	[53]
Fucoxanthinol, amarouciaxanthin A	Metabolites of fucoxanthin	Inhibitory effect against PC-3, prostate cancer cell line	[13]
Fucoxanthin	U. pinnatifida	Inhibitory effect against HCT116, human colorectal adenocarcinoma	[54]
Fucoxanthin	U. pinnatifida	Induction of apoptosis in PC-3 cells via caspase-3 activation	[52]
Fucoxanthin	L. japonica	Cell cycle arrest at G0/G1 phase in human colon cancer cells induced by upregulation of p21^WAF1/Cip1	[44]
Fucoxanthin	Unmentioned	Induction of G1 arrest and GADD45A gene expression in HepG2 and DU145 cells	[55]
Fucoxanthin	U. pinnatifida	Antiadult T-cell leukemia activity	[45]
Fucoxanthinol	Metabolites of fucoxanthin	In vivo and in vitro antiadult T-cell leukemia activity	[45]
Fucoxanthinol	L. japonica	Inhibitory effect against HepG2, human hepatic carcinoma, associated with downregulation of cyclin D	[56]
Fucoxanthin	U. pinnatifida	Induction of cell cycle arrest in G2/M phase and apoptosis in MGC-803 cells, human gastric adenocarcinoma	[58]