Mink S38G Gene Polymorphism and Atrial Fibrillation in the Chinese Population: A Meta-Analysis of 1871 Participants
Table 2
Summary of meta-analysis of association of Mink S38G gene polymorphism and atrial fibrillation (AF) in the Chinese population.
Genetic model
Pooled OR (95% CI)
value
Study number
AF size
Control size
Allelic genetic model
1.380 (1.200–1.600)
<0.00001*
6
856
1015
0.140 (39.8%)
Recessive genetic model
1.193 (1.033–1.377)
0.017*
6
856
1015
0.057* (53.5%)
Subgroup 1: SG1 < 60
1.320 (0.974–1.789)
0.073
3
265
302
0.055* (65.6%)
Subgroup 2: SG1 ≥ 60
1.162 (1.036–1.302)
0.010*
3
591
713
0.106 (55.4%)
Dominant genetic model
1.057 (1.025–1.089)
<0.00001*
6
856
1015
0.437 (0%)
Additive genetic model
1.105 (1.036–1.178)
0.002*
6
856
1015
0.066* (51.6%)
Subgroup 1: SG1 < 60
1.177 (1.017–1.361)
0.029*
3
265
302
0.038* (69.4%)
Subgroup 2: SG1 ≥ 60
1.078 (1.024–1.135)
0.004*
3
591
713
0.316 (13.1%)
Homozygous genetic model
1.128 (1.068–1.191)
<0.00001*
6
856
1015
0.180 (34.1%)
Heterozygous genetic model
1.078 (1.014–1.146)
0.016*
6
856
1015
0.627 (0.0%)
. Abbreviations: AF: atrial fibrillation; CI: confidence interval; OR: odds ratio; AF size: the total number of AF cases; control size: the total number of control group; allelic genetic model: G allele distribution frequency; recessive genetic model: GG versus SG + SS; dominant genetic model: SG + GG versus SS; additive genetic model: total G allele versus total S allele; homozygous genetic model: GG versus SS; heterozygous genetic model: SG versus SS; SG1: SG genotype number of AF group.
