Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis
Platelet-activation mechanisms and role of the P2Y12 receptor. Platelet activation leads to dense-granule secretion of ADP, which activates P2Y12, inducing amplification of aggregation, procoagulant, and proinflammatory responses (adapted from Storey, 2008 ).
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.