The Scientific World Journal / 2014 / Article / Fig 1

Review Article

Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis

Figure 1

Platelet-activation mechanisms and role of the P2Y12 receptor. Platelet activation leads to dense-granule secretion of ADP, which activates P2Y12, inducing amplification of aggregation, procoagulant, and proinflammatory responses (adapted from Storey, 2008 [7]).

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