The Scientific World Journal / 2014 / Article / Tab 2

Review Article

Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis

Table 2

A comparison of endothelial and platelet properties (adapted from Warkentin et al., 2003 [21]).

EndotheliumPlatelets

NucleusYesNo
mRNALotsLittle but active
Cell dimensionsHighly variable: up to 100  M length in large vesselsDiameter ~4  M, volume 7–12 fL
(inversely proportional to platelet count)
Life spanLong (months to years)Short (7–9 days)
Daily productionNot known2.5 × 1011
CirculatingFewMost (normally 1/3 sequestered in spleen; may become sequestered on activated endothelium)
Diagnostic markersIndirect and not clinically usefulCBC, peripheral smear, platelet function studies
OriginBone marrowBone marrow
Storage granulesWeibel-Palade bodiesα granules, dense granules, lysosomes
Partial list of storage componentsvWf, P-selectin, multimerinvWf, P-selectin, multimerin, fibrinogen, PDGF, TGF-β, IL-1, VEGF, angiopoietin, RANTES, PF4, ADP, ATP, serotonin

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