The Scientific World Journal / 2014 / Article / Tab 3

Review Article

Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis

Table 3

Clinical assessment of platelet functions.

Platelet aggregometry

Photo-optical platelet aggregometry [79]Platelet-rich plasma is taken to check the platelet aggregation.
Impedance platelet aggregometry [80]Platelet aggregation is checked by using the whole blood by electrical impedance.
Light-scattering platelet aggregometry [81]It is a combination of laser light scattering and aggregometry to monitor platelet microaggregate formation.

Point-of-care for platelet function tests

Ultegra rapid platelet function assay (RPFA) [82]RPFA is a simple and fast, automated point-of-care device that monitors GPIIb-IIIa inhibition. This test is based on platelet agglutination from interaction between unblocked GPIIb-IIIa receptors and fibrinogen-coated beads.
Platelet-activating clotting test (PACT) assay [83]The PACT assay, HemoSTATUS, measures ACT without a platelet activator, comparing it with ACTs obtained with increasing concentrations of platelet-activating factor (PAF).
Platelet function analyzer (PFA-100) [84]PFA-100 exposes platelets within citrated whole blood to high shear stress through a capillary tube, followed by an aperture in a membrane coated with collagen and either ADP or epinephrine. The platelets adhere and aggregate until the aperture is occluded, and the time to this closure is recorded.
Plateletworks test [85]The Plateletworks is a point-of-care test that uses a Coulter counter to measure platelet-count ratio, red blood cell count, hemoglobin, and hematocrit. Platelet count is measured in a control sample in which aggregation is prevented by EDTA and compared with the platelet count in an agonist-stimulated (ADP or collagen) sample.
Clot signature analyzer [86]This test uses nonanticoagulated whole blood and can measure several aspects of platelet function and clotting properties.
Thromboelastography [87]This device measures clot strength and gives a global assessment of hemostasis.

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