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The Scientific World Journal
Volume 2014, Article ID 785140, 7 pages
http://dx.doi.org/10.1155/2014/785140
Research Article

Effects of Voltage-Gated K+ Channel on Cell Proliferation in Multiple Myeloma

1Department of Hematology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, China
2The Second Affiliated Hospital of Harbin Medical University, College of Nursing, Harbin 150086, China

Received 26 February 2014; Revised 12 May 2014; Accepted 12 May 2014; Published 8 June 2014

Academic Editor: Jean-Marc Sabatier

Copyright © 2014 Wei Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. J. Blackiston, K. A. McLaughlin, and M. Levin, “Bioelectric controls of cell proliferation: ion channels, membrane voltage and the cell cycle,” Cell Cycle, vol. 8, no. 21, pp. 3519–3528, 2009. View at Google Scholar · View at Scopus
  2. N. Bobak, S. Bittner, J. Andronic et al., “Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels,” Biochimica et Biophysica Acta—Biomembranes, vol. 1808, no. 8, pp. 2036–2044, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Y. Yoo, H. Zheng, J. H. Nam et al., “Facilitation of Ca2+-activated K+ channels (IKCa1) by mibefradil in B lymphocytes,” Pflugers Archiv European Journal of Physiology, vol. 456, no. 3, pp. 549–560, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Beeton, J. Barbaria, P. Giraud et al., “Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation,” Journal of Immunology, vol. 166, no. 2, pp. 936–944, 2001. View at Google Scholar · View at Scopus
  5. G. Ciapetti, L. Ambrosio, G. Marletta, N. Baldini, and A. Giunti, “Human bone marrow stromal cells: in vitro expansion and differentiation for bone engineering,” Biomaterials, vol. 27, no. 36, pp. 6150–6160, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. N. Ma, H. Gai, J. Mei et al., “Bone marrow mesenchymal stem cells can differentiate into type II alveolar epithelial cells in vitro,” Cell Biology International, vol. 35, no. 12, pp. 1261–1266, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. W. H. Schuette, S. E. Shackney, F. A. Plowman, H. W. Tipton, C. A. Smith, and M. A. MacCollum, “Design of flow chamber with electronic cell volume capability and light detection optics for multilaser flow cytometry,” Cytometry, vol. 5, no. 6, pp. 652–656, 1984. View at Google Scholar · View at Scopus
  8. I. Grgic, H. Wulff, I. Eichler, C. Flothmann, R. Köhler, and J. Hoyer, “Blockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection,” Transplantation Proceedings, vol. 41, no. 6, pp. 2601–2606, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. K. A. Woodfork, W. F. Wonderlin, V. A. Peterson, and J. S. Strobl, “Inhibition of ATP-sensitive potassium channels causes reversible cell-cycle arrest of human breast cancer cells in tissue culture,” Journal of Cellular Physiology, vol. 162, no. 2, pp. 163–171, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. J.-M. Dubois and B. Rouzaire-Dubois, “Role of potassium channels in mitogenesis,” Progress in Biophysics and Molecular Biology, vol. 59, no. 1, pp. 1–21, 1993. View at Google Scholar · View at Scopus
  11. H. Wulff, N. A. Castle, and L. A. Pardo, “Voltage-gated potassium channels as therapeutic targets,” Nature Reviews Drug Discovery, vol. 8, no. 12, pp. 982–1001, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Cidad, L. Jiménez-Pérez, D. García-Arribas et al., “Kv1.3 channels can modulate cell proliferation during phenotypic switch by an ion-flux independent mechanism,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 5, pp. 1299–1307, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. S. H. Jang, S. Y. Choi, P. D. Ryu, and S. Y. Lee, “Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo,” European Journal of Pharmacology, vol. 651, no. 1–3, pp. 26–32, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Lam and H. Wulff, “The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression,” Drug Development Research, vol. 72, no. 7, pp. 573–584, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. R. J. Leonard, M. L. Garcia, R. S. Slaughter, and J. P. Reuben, “Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: Mechanism of the antiproliferative effect of charybdotoxin,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 21, pp. 10094–10098, 1992. View at Google Scholar · View at Scopus
  16. P. A. Negulescu, N. Shastri, and M. D. Cahalan, “Intracellular calcium dependence of gene expression in single T lymphocytes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 7, pp. 2873–2877, 1994. View at Google Scholar · View at Scopus
  17. L. A. Pardo, “Voltage-gated potassium channels in cell proliferation,” Physiology, vol. 19, no. 5, pp. 285–292, 2004. View at Google Scholar · View at Scopus
  18. K. Kunzelmann, “Ion channels and cancer,” Journal of Membrane Biology, vol. 205, no. 3, pp. 159–173, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Matsuda, H. Kawasaki, T. Moriguchi, Y. Gotoh, and E. Nishida, “Activation of protein kinase cascades by osmotic shock,” The Journal of Biological Chemistry, vol. 270, no. 21, pp. 12781–12786, 1995. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Rouzaire-Dubois, M. Malo, J.-B. Milandri, and J.-M. Dubois, “Cell size-proliferation relationship in rat glioma cells,” GLIA, vol. 45, no. 3, pp. 249–257, 2004. View at Publisher · View at Google Scholar · View at Scopus