|
| Study ID | Design; year of study; country | Definition of short and long duration | Total number in short duration group | Total number in longer duration group | Follow-up duration | Outcomes evaluated |
|
|
Gwon et al. 2012 (EXCELLENT trial) [6] | Open-label RCT; June 2008–July 2009; South Korea. | Short: 6 months. Long: 12 months. | 722 | 721 | 1 year after index PCI. | Primary: target vessel failure—composite of cardiac death, myocardial infarction, or target vessel revascularization.
Secondary: death from any cause; death or myocardial infarction; stent thrombosis; major bleeding; major adverse cardiocerebral events—composite of death, myocardial infarction, cerebrovascular accident, or any revascularization; safety endpoint—composite of death, myocardial infarction, cerebrovascular accident, stent thrombosis, or thrombolysis In myocardial infarction major bleeding. |
|
|
Hu and Wang 2012 [10] | Double-blind RCT; September 2008–October 2011; China. | Short: 12 months.
Long: >36 months. | 88 | 94 | 3 years after PCI. | Primary (12 months onwards): target vessel failure, defined as target vessel-related cardiac death or myocardial infarction and target vessel revascularization.
Secondary outcomes included stent thrombosis. |
|
|
Kim et al. 2012 (RESET trial) [7] | Open-label RCT; April 2009–December 2010; South Korea. | Short: 3 months.
Long: 12 months. | 1,059 | 1,058 | 1 year. | Primary: cardiovascular death, myocardial infarction, stent thrombosis, ischemia driven target vessel revascularization, bleeding.
Secondary: individual components of primary endpoint plus nontarget vessel revascularization, cerebrovascular accident. |
|
|
Park et al. 2010 (REAL-LATE and ZEST-LATE) [8] | Open-label RCT; July 2007–September 2008; South Korea. | Short: 12 months.
Long: 24 months. | 1,344 | 1,357 | Median duration of follow-up 19.2 months after randomization. | Primary: (12 months onwards) myocardial infarction or death from cardiac causes.
Secondary: death from any cause; myocardial infarction; cerebrovascular accident; stent thrombosis; repeated revascularization; a composite of myocardial infarction or death from any cause; a composite of myocardial infarction, cerebrovascular accident, or death from any cause; a composite of myocardial infarction, cerebrovascular accident, or death from cardiac causes; and major bleeding. |
|
|
Valgimigli et al. 2012 (PRODIGY) [9] | Open-label RCT; December 2006–December 2008; Italy. | Short: 6 months.
Long: 24 months. | 983 | 987 | 2 years. | Primary: 30-day to 24-month incidence of death from any cause, nonfatal myocardial infarction, or cerebrovascular accident.
Secondary: each component of primary outcome, cardiovascular death, the incidence of stent thrombosis, and bleeding outcomes. |
|
