Protective Effect of Hesperetin and Naringenin against Apoptosis in Ischemia/Reperfusion-Induced Retinal Injury in Rats

Table 1

Thickness of the rat’s retina (μm).

	GCL	IPL	INL	OPL	ONL
Control	21.8 ± 5.2	50.4 ± 6.4	25.2 ± 5.1	12.1 ± 1.8	50 ± 9.8
Sham	13.4 ± 2.6*	20.2 ± 3.9*	15.6 ± 2.5*	8.6 ± 2.0*	40 ± 6.4*
Solvent	11.3 ± 4.1*	21.3 ± 3.5*	16.2 ± 4.2*	8.1 ± 2.1*	42 ± 8.7*
Hesperetin treatment	9.5 ± 3.1**	20.7 ± 5.4*	17.4 ± 3.7*	8.5 ± 1.7*	32 ± 6.3**
Naringenin treatment	12.2 ± 3.1*	25.4 ± 2.7***	24.2 ± 1.8^#	9.5 ± 1.4***	47.6 ± 3.4^#

GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer.
^∗𝑃<0.05: comparison to control; **P < 0.05: comparison to control, sham, solvent, and naringenin groups; ***P < 0.05: comparison to control, sham, solvent, and hesperetin treatment groups; ^#P < 0.05: comparison to sham, solvent groups, and hesperetin treatment groups.