Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models

Table 4

Effect of X. laevigata leaf essential oil (EOX) or indomethacin (INDO) on carrageenan-induced leukocyte migration and carrageenan-induced hindpaw edema in mice.

Treatment	Dose; (mg/kg)	Carrageenan-induced leukocyte migration (leukocytes ×10^6/mL)^a	% inhibition	Carrageenan-induced hindpaw edema volume (mL)^a	% inhibition
Vehicle	—	48.3 ± 2.8	—	0.61 ± 0.14	—
EOX	12.5	32.1 ± 3.6^b	33.5^d	0.40 ± 0.11^b	34.4^d
EOX	25	30.7 ± 2.2^b	36.4^d	0.36 ± 0.09^b	41.0^d
EOX	50	27.8 ± 4.3^c	42.4^d	0.34 ± 0.11^b	44.3^d
INDO	10	19.7 ± 2.5^c	59.2^e	0.21 ± 0.08^c	65.6^e

𝑛=6, per group. ^aValues represent mean ± S.E.M. ^b𝑃<0.01 (one-way ANOVA and Tukey’s test), significantly different from control. ^c𝑃<0.001 (one-way ANOVA and Tukey’s test), significantly different from control. ^d𝑃<0.01 (Fisher’s test), significantly different from control. ^e𝑃<0.001 (Fisher’s test), significantly different from control.