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The Scientific World Journal
Volume 2014, Article ID 816545, 6 pages
Research Article

Effects of Traditional Chinese Medicine Shuxuetong Injection on Random Skin Flap Survival in Rats

1Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, No. 109, XueYuan Road (West), Lucheng, Wenzhou, Zhejiang 325000, China
2Department of Anesthesia, The Children's Hospital Zhejiang University School of Medicine, No. 57 Zhugan Lane, Hangzhou, Zhejiang 310006, China

Received 12 December 2013; Accepted 23 January 2014; Published 26 February 2014

Academic Editors: H. Acker and N. C. Gorin

Copyright © 2014 Leyi Cai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. A Shuxuetong injection is traditionally used in Chinese medicine to treat “blood stasis and stagnation” (yu xue yu zhi). We investigated the effect of such injection on the survival of random skin flaps. Methods. McFarlane flaps were established in 60 rats divided into two groups. Postoperative celiac injections were given to both groups for 7 days. Shuxuetong was injected into the test group, and saline was injected into controls. On day 7, tissues were stained with H&E (hematoxylin-eosin) stain, immunohistochemically evaluated, and the expression levels of xanthine oxidase were determined. Result. The mean area of flap survival in the test group was significantly higher than in controls. Expression of vascular endothelial growth factor and superoxide dismutase, and microvessel development, were markedly increased in the test group, and the malondialdehyde level was reduced. Conclusion. Shuxuetong promotes random skin flap survival.