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The Scientific World Journal
Volume 2014, Article ID 821524, 5 pages
Research Article

Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver

1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51656-65811, Iran
2Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran
3Dental School, Tabriz University of Medical Sciences, Tabriz 51656-65814, Iran

Received 18 August 2013; Accepted 12 January 2014; Published 20 February 2014

Academic Editors: W. Gelderblom, C. Montoliu, and A. Okada

Copyright © 2014 Mustafa Mohammadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of the present study is to investigate the effects of caloric restriction on liver of lead-administered rat. Male Sprague-Dawley rats were randomly divided into two groups: Ad libitum fed group (AL, free access to normal rat chow) and caloric restriction group (CR, fed 65% of AL animals’ food intake). After 6 weeks, half of the animals of each group were injected lead acetate and the other half were injected saline. Liver tissue samples were collected at the end of the experiments. Glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA), and tumor necrosis factor (TNF-α) were measured in the tissue extracts. Histological studies were also performed. Our results showed that lead administrations (not saline injections) reduced liver SOD and GPx and increased MDA and TNF-α in AL animals, but in the CR animals lead injections did not significantly change the measured parameters. The histological studies supported the biochemical findings. We concluded that 65% CR may prevent lead-induced oxidative stress and inflammation in rat liver.