Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver
Liver tumor necrosis factor-α (TNF-α) in ad libitum (AL) and caloric restriction (CR) groups after lead or saline administrations. Seven days of lead injections (15 mg/Kg body weight, ip) to AL animals caused significant raise of liver TNF-α (* compared to the saline injected AL); in CR animals TNF-α changes after the same dose lead administration were not significant. Liver TNF-α was significantly lower in lead-administered CR compared to lead-administered AL (# compared to the lead-injected AL). The data are presented as means ± SEM.