Nanospray Drying as a Novel Technique for the Manufacturing of Inhalable NSAID Powders

Table 4

Aerodynamic properties of Klys/leu powders sprayed through a surfactant treated nozzle (70°C, 4 µm nozzle, and 6% w/v feed) after ACI experiments: emitted dose (ED), mass median aerodynamic diameter (MMAD), fine particles fraction (FPF), and fine particle dose (FPD).

Batch	Leu concentration (% w/w)	Water/IPA (% v/v)	Emitted dose (%)	MMAD (µm)	FPF (%)	FPD (mg)
#5d	10%	70/30	98.4 ± 2.9	4.25 ± 0.12	54.4 ± 0.3	15.8 ± 0.4
#10	15%	100/0	100.1 ± 0.1	4.02 ± 0.05	54.8 ± 1.1	18.2 ± 0.7
#11	15%	90/10	99.7 ± 0.3	3.83 ± 0.02	60.9 ± 1.2	18.0 ± 0.4
#12	15%	80/20	99.9 ± 0.2	4.19 ± 0.20	55.3 ± 2.5	16.6 ± 1.1
#13	10%	90/10	100.8 ± 0.1	4.31 ± 0.22	49.9 ± 3.2	15.5 ± 0.9