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The Scientific World Journal
Volume 2014, Article ID 847368, 9 pages
Research Article

The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar Rats

1Department of Bioorganic Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland
2State Higher Vocational School, Institute of Health, Staszica 1 Street, 33-300 Nowy Sacz, Poland
3Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland
4Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Yuzuncu Yıl University, Zeve Campus, 65080 Van, Turkey
5Department of Mechanical Engineering and Agrophysics, Faculty of Production Engineering and Energetics, University of Agriculture in Krakow, 116 B Balicka Street, 30-149 Krakow, Poland

Received 7 January 2014; Revised 11 July 2014; Accepted 23 July 2014; Published 16 October 2014

Academic Editor: João B. T. Da Rocha

Copyright © 2014 Renata Francik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cornelian cherry (Cornus mas) is a valuable source of phenolic antioxidants. Flavonoid derivatives as nonenzymatic antioxidants are important in the pathophysiology of many diseases including neurological disorders (e.g., Alzheimer’s disease) or heart disease. In this study, we examined the effect of an addition of freeze-dried fruit of cornelian cherry on three types of diets: control diet, fructose diet, and diet enriched in fats (high-fat diet). This effect was studied by determining the following antioxidant parameters in both brain tissue and plasma in rats: catalase, ferric reducing ability of plasma, paraoxonase, protein carbonyl groups, and free thiol groups. Results indicate that both fructose diet and high-fat diet affect the antioxidant capacity of the organism. Furthermore, an addition of cornelian cherry resulted in increased activity of catalase in brain tissue, while in plasma it caused the opposite effect. In turn, with regard to paraoxonase activity in both brain tissue and plasma, it had a stimulating effect. Adding cornelian cherry to the tested diets increased the activity of PON in both tested tissues. Moreover, protective effect of fruits of this plant was observed in the process of oxidation of proteins by decreasing levels of protein carbonyl groups and thiol groups in brain tissue as well as in plasma.