PEEP Role in ICU and Operating Room: From Pathophysiology to Clinical Practice

Table 2

Main characteristics of RCTs for ARDS patients included in this study.

Author	Year	Patients	Low PEEP level	High PEEP level
Amato et al. [38]	1998	ARDS	≥5 cm H2O	16 cm H2O or Pflex + 2
Ranieri et al. [39]	1999	ARDS	3–15 cm H2O	15 cm H2O or Pflex + 3
The NHLBI Institute ARDS Clinical Trial Network [40]	2004	ALI/ARDS	5 cm H2O	5–24 cm H2O according FiO2
Villar et al. [50]	2006	ARDS	≥5 cm H2O	15 cm H2O or Pflex + 3
Mercat et al. [41]	2008	ALI/ARDS	5–9 cm H2O	PEEP according to Plateau 28–30 cm H2O
Meade et al. [42]	2008	ALI/ARDS	5 cm H2O	5–24 according FiO2
Talmor et al. [43]	2008	ALI/ARDS	10 cm H2O	17 cm H2O