Hematopoietic and Mesenchymal Stem Cells for the Treatment of Chronic Respiratory Diseases: Role of Plasticity and Heterogeneity

Table 1

Characteristics of marrow-derived stem cell subpopulations in murine models.

Subpopulation	Size	Phenotype	Marrow-derived epithelial cells in the lung	Reference
ELH^1	<5 𝜇m	Lin^−	Yes	[26]
LSK^2	ND	Lin^−, Sca-1^+, Kit^+	No	[45]
MAPCs^3	8–10 𝜇m	Flk-1^+, Sca-1^+, Thy-1^+, CD13^+, SSEA-1^+	Yes	[53]
SSEA-1^4		Lin^−, CD45^−, CD31^+, Sca-1^+, CD105^+, CD73^+, CD44^+, vimentin^+	ND	[127]
VSELs^5	2–4  𝜇m	Lin^−, Sca-1^+, CD45^−, SSEA-1^+, Oct-4^+, Nanog^+	Yes	[125]
Ccsp^6	5–10 𝜇m	CD45^+, CD34^+, CD73^+, CD90^+, CD105^+	Yes	[119]
R1/R2 CFTR^7	ND	Lin^−, Sca-1^+, CFTR^+	ND	[128]

1Elutriation (E), lineage depletion (L), ability to home (H) to the BM; ²Lineage-negative (L), Sca⁺ (S), Kit⁺ (K); ³Multipotent adult progenitor cells; ⁴Stage-specific embryonic antigen 1; ⁵Very small, embryonic-like cells; ⁶Clara cell secretory protein; ⁷Cystic fibrosis transmembrane conductance regulator. ND: not determined.