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The Scientific World Journal
Volume 2014, Article ID 896206, 6 pages
http://dx.doi.org/10.1155/2014/896206
Review Article

Competing Endogenous RNA: The Key to Posttranscriptional Regulation

1Gyanxet, BF 286 Salt Lake, Kolkata, West Bengal 700064, India
2Indian Association for the Cultivation of Science, Kolkata, West Bengal 700032, India

Received 22 August 2013; Accepted 10 December 2013; Published 2 February 2014

Academic Editors: C. Lecoeur, C. Y. Liu, and A. C. Manna

Copyright © 2014 Rituparno Sen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Competing endogenous RNA, ceRNA, vie with messenger RNAs (mRNAs) for microRNAs (miRNAs) with shared miRNAs responses elements (MREs) and act as modulator of miRNA by influencing the available level of miRNA. It has recently been discovered that, apart from protein-coding ceRNAs, pseudogenes, long noncoding RNAs (lncRNAs), and circular RNAs act as miRNA “sponges” by sharing common MRE, inhibiting normal miRNA targeting activity on mRNA. These MRE sharing elements form the posttranscriptional ceRNA network to regulate mRNA expression. ceRNAs are widely implicated in many biological processes. Recent studies have identified ceRNAs associated with a number of diseases including cancer. This brief review focuses on the molecular mechanism of ceRNA as part of the complex post-transcriptional regulatory circuit in cell and the impact of ceRNAs in development and disease.