Review Article

Competing Endogenous RNA: The Key to Posttranscriptional Regulation

Table 1

A list of ceRNAs reported to be associated with diseases.

ceRNAsShared targeting miRNA(s)Involved in disease

PTEN
and ZEB2
miR-181, miR-200b, miR-25, and miR-92Melanoma [11]

PTEN
and CNOT6L (miR-17, 19a, 19b, 20a, 20b, and 106b)
VAPA (miRs 17, 19a, 20a, 20b, 26b, 106a, and 106b)
miRs 17, 19a, 20a, 20b, 26b, 106a, 106b, and 19bProstate cancer [12]

PTEN
and 13 ceRNAs including RB1, NRAS, KLF6, HIF1A, HIAT1, CTBP2, and TNKS2
It is predicted that PTEN and RB1 share MRE for 32 common miRNAs [7]Glioblastoma [13]

CD44
and CDC42
miR-216a, miR-330, and miR-608Breast cancer and many other cancers [14]

Versican
and Rb1
PTEN
miR-199a-3p and miR-144Breast cancer [15]

PTEN
and PTENP1
miR-19b and miR-20aControls downstream PI3K signalling and cell proliferation in several cancers [8]

PRKACB
and HULC
miR-372Hepatocellular carcinoma [16]

PTCSC3
and targets of miR-574-5p
miR-574-5pThyroid cancer [17]

LMNA
and 17 ceRNAs (predicted)
11 miRNAs including miR-9, miR-34a, miR-539, miR-449a, and miR-671 [16]Hutchinson-Gilford progeria syndrome [18]

HSUR (HVS)miRNA-27Controls host-virus interaction in HVS infected T cells [19]