Design, Synthesis, Molecular Docking, and Antibacterial Evaluation of Some Novel Flouroquinolone Derivatives as Potent Antibacterial Agent

Table 1

Physical data of synthesis of 1-ethyl-6-fluoro-4-oxo-7-{4-[2-(4-substituted phenyl)-2-(substituted)-ethyl]-1-piperazinyl}-1,4-dihydroquinoline-3-carboxylic acid (8a–8t).

Sr. number	Comp. number			Mol. wt.	Molecular formula	Yield (%)	Melting point (°C)
1	8a	–H	–NHC6H5	527	C30H30F1N5O3	72	189–191	0.66
2	8b	–H	–NH2	451	C24H26F1N5O3	50	204–206	0.39
3	8c	–H	–OH	452	C24H25F1N4O4	64	201–203	0.37
4	8d	–H	–NHCONH2	494	C25H27F1N6O4	54	252–254	0.41
5	8e	–H	–OCH3	466	C25H27FN4O4	60	231–234	0.54
6	8f	–OCH3	–NHC6H5	557	C31H32F1N5O4	70	228–230	0.60
7	8g	–OCH3	–NH2	481	C25H28F1N5O4	60	160–162	0.39
8	8h	–OCH3	–OH	482	C25H27F1N4O5	55	215–218	0.35
9	8i	–OCH3	–NHCONH2	524	C26H29F1N6O5	62	242–245	0.41
10	8j	–OCH3	–OCH3	496	C26H29FN4O5	61	235–238	0.54
11	8k	–CH3	–NHC6H5	541	C31H32F1N5O3	64	227–230	0.62
12	8l	–CH3	–NH2	465	C25H28F1N5O3	53	198–201	0.37
13	8m	–CH3	–OH	466	C25H27F1N4O4	58	242–244	0.35
14	8n	–CH3	–NHCONH2	508	C26H29F1N6O4	61	158–160	0.43
15	8o	–CH3	–OCH3	480	C26H29F1N4O4	65	202–204	0.58
16	8p	–NO2	–NHC6H5	572	C30H29FN6O5	54	228–230	0.62
17	8q	–NO2	–NH2	496	C24H25FN6O5	62	177–180	0.58
18	8r	–NO2	–OH	497	C24H24FN5O6	69	258–260	0.52
19	8s	–NO2	–NHCONH2	539	C25H26FN7O6	72	207–209	0.58
20	8t	–NO2	–OCH3	511	C25H26FN5O6	70	230–232	0.62

Mobile phase: chloroform : hexane : methanol (9 : 0.5 : 0.5).