Research Article
Design, Synthesis, Molecular Docking, and Antibacterial Evaluation of Some Novel Flouroquinolone Derivatives as Potent Antibacterial Agent
Table 2
In vitro antibacterial activity of synthesized compounds against Gram-positive and Gram-negative bacteria (MICs in µg/mL).
| Minimum inhibitory concentrations (g∖mL) | Sr. number | Comp. number | | | S. aureus | S. pneumonia | P. aeruginosa | E. coli | ATCC-29213 | ATCC-49619 | ATCC-27853 | ATCC-25922 |
| 1 | 8a | –H | –NHC6H5 | 50 | 100 | 100 | 25 | 2 | 8b | –H | –NH2 | 25 | 100 | 100 | 12.5 | 3 | 8c | –H | –OH | 50 | 100 | 100 | 50 | 4 | 8d | –H | –NHCONH2 | 12.5 | 100 | 100 | 25 | 5 | 8e | –H | –OCH3 | 50 | >100 | >100 | 50 | 6 | 8f | –OCH3 | –NHC6H5 | 25 | 100 | 100 | 25 | 7 | 8g | –OCH3 | –NH2 | 6.25 | 12.5 | 100 | 12.5 | 8 | 8h | –OCH3 | –OH | 6.25 | 50 | 100 | 12.5 | 9 | 8i | –OCH3 | –NHCONH2 | 6.25 | 12.5 | 50 | 12.5 | 10 | 8j | –OCH3 | –OCH3 | 50 | 100 | 100 | 50 | 11 | 8k | –CH3 | –NHC6H5 | 50 | 100 | >100 | 25 | 12 | 8l | –CH3 | –NH2 | 12.5 | 25 | 100 | 25 | 13 | 8m | –CH3 | –OH | 50 | 100 | 100 | 50 | 14 | 8n | –CH3 | –NHCONH2 | 6.25 | 25 | 50 | 12.5 | 15 | 8o | –CH3 | –OCH3 | 25 | 100 | >100 | 25 | 16 | 8p | –NO2 | –NHC6H5 | 50 | 100 | >100 | 50 | 17 | 8q | –NO2 | –NH2 | 12.5 | 25 | 50 | 12.5 | 18 | 8r | –NO2 | –OH | 6.25 | 50 | 100 | 12.5 | 19 | 8s | –NO2 | –NHCONH2 | 6.25 | 12.5 | 50 | 6.25 | 20 | 8t | –NO2 | –OCH3 | 25 | 100 | 100 | 25 | 21 | Norfloxacin | 1 | 6.25 | 6.25 | 1 |
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