Research Article

Design, Synthesis, Molecular Docking, and Antibacterial Evaluation of Some Novel Flouroquinolone Derivatives as Potent Antibacterial Agent

Table 2

In vitro antibacterial activity of synthesized compounds against Gram-positive and Gram-negative bacteria (MICs in µg/mL).

Minimum inhibitory concentrations (g∖mL)
Sr. numberComp. numberS. aureus S. pneumonia P. aeruginosa E. coli
ATCC-29213 ATCC-49619 ATCC-27853 ATCC-25922

18a–H–NHC6H55010010025
28b–H–NH22510010012.5
38c–H–OH5010010050
48d–H–NHCONH212.510010025
58e–H–OCH350>100>10050
68f–OCH3–NHC6H52510010025
78g–OCH3–NH26.2512.510012.5
88h–OCH3–OH6.255010012.5
98i–OCH3–NHCONH26.2512.55012.5
108j–OCH3–OCH35010010050
118k–CH3–NHC6H550100>10025
128l–CH3–NH212.52510025
138m–CH3–OH5010010050
148n–CH3–NHCONH26.25255012.5
158o–CH3–OCH325100>10025
168p–NO2–NHC6H550100>10050
178q–NO2–NH212.5255012.5
188r–NO2–OH6.255010012.5
198s–NO2–NHCONH26.2512.5506.25
208t–NO2–OCH32510010025
21Norfloxacin16.256.251