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The Scientific World Journal
Volume 2014, Article ID 898746, 7 pages
Research Article

Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction

1University Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
2Institute for Biomedical Statistics, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
3Clinic for Internal Disease Intermedica, 18000 Nis, Serbia
4Institute for Endocrinology, Metabolic Disease and Obesity, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia

Received 27 November 2013; Accepted 22 January 2014; Published 27 February 2014

Academic Editors: S. Di Filippo and Y. Murakawa

Copyright © 2014 Lisulov Popovic Danica et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of the study was to evaluate whether obstructive sleep apnea (OSA) contributes directly to left ventricular (LV) diastolic and regional systolic dysfunction in newly diagnosed OSA with normal left ventricle ejection fraction. Methods. 125 consecutive patients were prospectively enrolled in the study. Control group consisted of 78 asymptomatic age-matched healthy subjects who did not have any cardiovascular and respiratory diseases. All patients had undergone overnight polysomnography and standard transthoracic and tissue Doppler imaging echocardiogram. Results. The E/A ratio and the peak E wave at mitral flow were significantly lower and the peak A wave at mitral flow was significantly higher in OSA patients compared with control subjects. Left ventricle isovolumetric relaxation time (IVRT) and mitral valve flow propagation (MVFP) were significantly longer in OSA patients than in controls. Tissue Doppler derived amplitude of lateral part at mitral valve ( ) and wave amplitudes both at the lateral ( ) and septal parts of the mitral valve ( ) were significantly lower in OSA patients compared to controls. Conclusion. Newly diagnosed OSA patients with normal global LV function have significantly impaired diastolic function and regional longitudinal systolic function. OSA is independently associated with these changes in LV function.