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The Scientific World Journal
Volume 2014 (2014), Article ID 902987, 8 pages
http://dx.doi.org/10.1155/2014/902987
Research Article

RHBDL2 Is a Critical Membrane Protease for Anoikis Resistance in Human Malignant Epithelial Cells

1Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2Cardiovascular Research Center, National Cheng Kung University, Tainan 701, Taiwan
3Department of Biochemistry, College of Medicine, Tzu Chi University, Hualien 970, Taiwan
4Biotechnology, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan
5Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
6Center for Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan

Received 10 February 2014; Revised 14 April 2014; Accepted 11 May 2014; Published 28 May 2014

Academic Editor: Luca Scorrano

Copyright © 2014 Tsung-Lin Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Stephen Wood, Josef Goldufsky, and Sasha H. Shafikhani, “Pseudomonas aeruginosa ExoT Induces Atypical Anoikis Apoptosis in Target Host Cells by Transforming Crk Adaptor Protein into a Cytotoxin,” Plos Pathogens, vol. 11, no. 5, 2015. View at Publisher · View at Google Scholar
  • Kakurina, Kondakova, and Choinzonov, “Degradome components in progression of squamous cell carcinoma of the head and neck,” Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, vol. 70, no. 6, pp. 684–693, 2015. View at Publisher · View at Google Scholar
  • Viorica L. Lastun, Adam Grieve, and Matthew Freeman, “Substrates and physiological functions of secretase rhomboid proteases,” Seminars in Cell & Developmental Biology, 2016. View at Publisher · View at Google Scholar
  • Kvido Strisovsky, “Rhomboid protease inhibitors: emerging tools and future therapeutics,” Seminars in Cell & Developmental Biology, 2016. View at Publisher · View at Google Scholar
  • Siniša Urban, “A guide to the rhomboid protein superfamily in development and disease,” Seminars in Cell and Developmental Biology, vol. 60, pp. 1–4, 2016. View at Publisher · View at Google Scholar
  • Nicholas Johnson, Jana Březinová, Elaine Stephens, Emma Burbridge, Matthew Freeman, Colin Adrain, and Kvido Strisovsky, “Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Stefan Düsterhöft, Ulrike Künzel, and Matthew Freeman, “Rhomboid proteases in human disease: Mechanisms and future prospects,” Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017. View at Publisher · View at Google Scholar