Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2014, Article ID 916713, 5 pages
http://dx.doi.org/10.1155/2014/916713
Research Article

In Vitro Vitamin K3 Effect on Conjunctival Fibroblast Migration and Proliferation

1Department of Ophthalmology, Lozano Blesa University Hospital, C/San Juan Bosco 15, 50009 Zaragoza, Spain
2Aragon Institute of Health Sciences (IIS Aragon), 50009 Zaragoza, Spain
3Department of Ophthalmology, Hospital García Orcoyen, Navarra, 31200 Estella, Spain
4Department of Ophthalmology, Complejo Hospitalario de Navarra, Navarra, 31008 Pamplona, Spain
5Department of Applied Physics, Zaragoza University, 50009 Zaragoza, Spain
6Department of Gastroenterology, Lozano Blesa University Hospital, C/San Juan Bosco 15, 50009 Zaragoza, Spain

Received 29 August 2013; Accepted 14 October 2013; Published 8 January 2014

Academic Editors: J. Aquavella and K. Unlu

Copyright © 2014 I. Pinilla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. J. Ryan, “Traction retinal detachment XLIX Edward Jackson Memorial Lecture,” The American Journal of Ophthalmology, vol. 115, no. 1, pp. 1–20, 1993. View at Google Scholar · View at Scopus
  2. F. Koerner, A. Merz, B. Gloor, and E. Wagner, “Postoperative retinal fibrosis—a controlled clinical study of systemic steroid therapy,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 219, no. 6, pp. 268–271, 1982. View at Google Scholar · View at Scopus
  3. A. García-Layana, M. T. Hernando, L. Manzanas, and J. C. Pastor, “Tratamiento profiláctico de la vitreorretinopatía proliferante,” Archivos de la Sociedad Española de Oftalmología, vol. 60, pp. 315–322, 1991. View at Google Scholar
  4. R. Fiscella, G. A. Peyman, J. Elvart, and B. Yue, “In vitro evaluation of cellular inhibitory potential of various antineoplastic drugs and dexamethasone,” Ophthalmic Surgery, vol. 16, no. 4, pp. 247–249, 1985. View at Google Scholar · View at Scopus
  5. M. S. Blumenkranz, A. Claflin, and A. S. Hajek, “Selection of therapeutic agents for intraocluar proliferative disease. Cell culture evaluation,” Archives of Ophthalmology, vol. 102, no. 4, pp. 598–604, 1984. View at Google Scholar · View at Scopus
  6. A. S. Berger, C. K. Cheng, P. A. Pearson et al., “Intravitreal sustained release corticosteroid-5-fluoruracil conjugate in the treatment of experimental proliferative vitreoretinopathy,” Investigative Ophthalmology and Visual Science, vol. 37, no. 11, pp. 2318–2325, 1996. View at Google Scholar · View at Scopus
  7. M. S. Blumenkranz, M. K. Hartzer, and A. S. Hajek, “Selection of therapeutic agents for intraocular proliferative disease. II. Differing antiproliferative activity of the fluoropyrimidines,” Archives of Ophthalmology, vol. 105, no. 3, pp. 396–399, 1987. View at Google Scholar · View at Scopus
  8. C. Verdoorn, V. W. Renardel de Lavalette, J. Dalma-Weizhausz, G. M. Orr, N. Sorgente, and S. J. Ryan, “Cellular migration, proliferation, and contraction. An in vitro approach to a clinical problem—proliferative vitreoretinopathy,” Archives of Ophthalmology, vol. 104, no. 8, pp. 1216–1219, 1986. View at Google Scholar · View at Scopus
  9. C. Heinz, T. Hudde, K. Heise, and K. P. Steuhl, “Antiproliferative effect of mycophenolate mofetil on cultured human Tenon fibroblasts,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 240, no. 5, pp. 408–414, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Heinz, K. Heise, T. Hudde, and K. P. Steuhl, “Mycophenolate mofetil inhibits human Tenon fibroblast proliferation by guanosine depletion,” The British Journal of Ophthalmology, vol. 87, no. 11, pp. 1397–1398, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Akimoto, T. Miyahara, J. Arai et al., “A new delivery system for 5-fluorouracil using prodrug and converting enzyme,” The British Journal of Ophthalmology, vol. 86, no. 5, pp. 581–586, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. V. Sundaram, A. Barsam, and G. Virgili, “Intravitreal low molecular weight heparin and 5-fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD006421, 2013. View at Google Scholar · View at Scopus
  13. M. Reibaldi, A. Russo, A. Longo et al., “Rhegmatogenous retinal detachment with a high risk of proliferative vitreoretinopathy treated with episcleral surgery and an intravitreal dexamethasone 0.7-mg implant,” Case Reports in Ophthalmology, vol. 4, no. 1, pp. 79–83, 2013. View at Publisher · View at Google Scholar
  14. P. Yang, B. S. McKay, J. B. Allen, and G. J. Jaffe, “Effect of NF-κ B inhibition on TNF-α-induced apoptosis in human RPE cells,” Investigative Ophthalmology and Visual Science, vol. 45, no. 7, pp. 2438–2446, 2004. View at Publisher · View at Google Scholar
  15. R. G. Williams, S. Chang, M. R. Comaratta, and G. Simoni, “Does the presence of heparin and dexamethasone in the vitrectomy infusate reduce reproliferation in proliferative vitreoretinopathy?” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 234, no. 8, pp. 496–503, 1996. View at Google Scholar · View at Scopus
  16. W. Chen, H. Chen, P. Hou, A. Fok, Y. Hu, and D. S. C. Lam, “Midterm results of low-dose intravitreal triamcinolone as adjunctive treatment for proliferative vitreoretinopathy,” Retina, vol. 31, no. 6, pp. 1137–1142, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. G. A. Williams, F. H. Lambrou, G. A. Jaffe et al., “Treatment of postvitrectomy fibrin formation with intraocular tissue activator,” Archives of Ophthalmology, vol. 106, no. 8, pp. 1055–1058, 1988. View at Google Scholar · View at Scopus
  18. R. N. Johnson and G. Blankenship, “A prospective, randomized, clinical trial of heparin therapy for postoperative intraocular fibrin,” Ophthalmology, vol. 95, no. 3, pp. 312–317, 1988. View at Google Scholar · View at Scopus
  19. S. Scheer, C. Morel, O. Touzeau, J. A. Sahel, and L. Laroche, “Pharmacological adjuvants for surgical treatment of proliferative vitreoretinopathy,” Journal Francais d'Ophtalmologie, vol. 27, no. 9, pp. 1051–1059, 2004. View at Google Scholar · View at Scopus
  20. D. G. Charteris, G. W. Aylward, D. Wong, C. Groenewald, R. H. Y. Asaria, and C. Bunce, “A randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in management of established proliferative vitreoretinopathy,” Ophthalmology, vol. 111, no. 12, pp. 2240–2245, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. M. A. Latina, S. J. Belmonte, C. Park, and E. Crean, “Gamma-interferon effects on human fibroblasts from Tenon's capsule,” Investigative Ophthalmology and Visual Science, vol. 32, no. 10, pp. 2806–2815, 1991. View at Google Scholar · View at Scopus
  22. L. M. Hjelmeland, J. W. Li, C. A. Toth, and M. B. Landers III, “Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 230, no. 1, pp. 84–90, 1992. View at Google Scholar · View at Scopus
  23. Y. Kang, D. A. Lee, and E. J. Higginbotham, “In vitro evaluation of antiproliferative potential of calcium channel blockers in human Tenon's fibroblasts,” Experimental Eye Research, vol. 64, no. 6, pp. 913–925, 1997. View at Publisher · View at Google Scholar · View at Scopus
  24. J. T. Handa, S. Murad, and G. J. Jaffe, “Minoxidil inhibits ocular cell proliferation and lysyl hydroxylase activity,” Investigative Ophthalmology and Visual Science, vol. 34, no. 3, pp. 567–575, 1993. View at Google Scholar · View at Scopus
  25. J. Wu and A. Danielsson, “Inhibition of hepatic fibrogenesis: a review of pharmacologic candidates,” Scandinavian Journal of Gastroenterology, vol. 29, no. 5, pp. 385–391, 1994. View at Google Scholar · View at Scopus
  26. L. Izaguirre, I. Pinilla, F. Gonzalvo, S. Pérez, and F. M. Honrubia, “Effect of doxorubicin on fibroblast migration and proliferation,” Annals of Ophthalmology, vol. 35, no. 1, pp. 48–52, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. J. J. Araiz, M. F. Refojo, M. H. Arroyo, F. L. Leong, D. M. Albert, and F. I. Tolentino, “Antiproliferative effect of retinoic acid in intravitreous silicone oil in an animal model of proliferative vitreoretinopathy,” Investigative Ophthalmology and Visual Science, vol. 34, no. 3, pp. 522–530, 1993. View at Google Scholar · View at Scopus
  28. J. W. Doyle, R. K. Dowgiert, and S. M. Buzney, “Factors modulating the effect of retinoids on cultured retinal pigment epithelial cell proliferation,” Current Eye Research, vol. 11, no. 8, pp. 753–765, 1992. View at Google Scholar · View at Scopus
  29. J. M. Larrosa, A. A. S. Veloso Jr., F. L. Leong, and M. F. Refojo, “Antiproliferative effect of intravitreal α-tocopherol and α-tocopheryl-acid-succinate in a rabbit model of PVR,” Current Eye Research, vol. 16, no. 10, pp. 1030–1035, 1997. View at Publisher · View at Google Scholar · View at Scopus
  30. J. M. Larrosa, V. Polo, T. Ramirez, I. Pinilla, L. E. Pablo, and F. M. Honrubia, “Alpha-tocopherol derivatives and wound healing in an experimental model of filtering surgery,” Ophthalmic Surgery and Lasers, vol. 31, no. 2, pp. 131–135, 2000. View at Google Scholar · View at Scopus
  31. I. Pinilla, J. M. Larrosa, V. Polo, E. Piazuelo, P. Jimenez, and F. M. Honrubia, “Comparison of fibroblast inhibitory effect of α-tocopherol succinate and 13-cis retinol,” Annals of Ophthalmology, vol. 34, no. 2, pp. 108–112, 2002. View at Google Scholar · View at Scopus
  32. C. H. Yang, T. F. Huang, K. R. Liu, M. S. Chen, and P. T. Hung, “Inhibition of retinal pigment epithelial cell-induced tractional retinal detachment by disintegrins, a group of Arg-Gly-Asp-containing peptides from viper venom,” Investigative Ophthalmology and Visual Science, vol. 37, no. 5, pp. 843–854, 1996. View at Google Scholar · View at Scopus
  33. Q. Gao, W. Wang, Y. Lan et al., “The inhibitory effect of small interference RNA protein kinase C-α on the experimental proliferative vitreoretinopathy induced by dispase in mice,” International Journal of Nanomedicine, vol. 8, pp. 1563–1572, 2013. View at Google Scholar
  34. R. T. Chlebowski, S. A. Akman, and J. B. Block, “Vitamin K in the treatment of cancer,” Cancer Treatment Reviews, vol. 12, no. 1, pp. 49–63, 1985. View at Google Scholar · View at Scopus
  35. D. Lim, R. J. Morgan Jr., S. Akman et al., “Phase I trial of menadiol diphosphate (vitamin K3) in advanced malignancy,” Investigational New Drugs, vol. 23, no. 3, pp. 235–239, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Oztopçu, S. Kabadere, A. Mercangöz, and R. Uyar, “Comparison of vitamins K1, K2, and K3 effects on growth of rat glioma and human glioblastoma multiforme cells in vitro,” Acta Neurologica Belgica, vol. 104, no. 3, pp. 106–110, 2004. View at Google Scholar · View at Scopus
  37. M. Ishibashi, M. Arai, S. Tanaka, K. Onda, and T. Hirano, “Antiproliferative and apoptosis-inducing effects of lipophilic vitamins on human melanoma A375 cells in vitro,” Biological and Pharmaceutical Bulletin, vol. 35, no. 1, pp. 10–17, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. B. R. Acharya, D. Choudhury, A. Das, and G. Chakrabarti, “Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity,” Biochemistry, vol. 48, no. 29, pp. 6963–6974, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. A. M. Marchionatti, G. Picotto, C. J. Narvaez, J. Welsh, and N. G. T. de Talamoni, “Antiproliferative action of menadione and 1, 25(OH)2D3 on breast cancer cells,” Journal of Steroid Biochemistry and Molecular Biology, vol. 113, no. 3-5, pp. 277–232, 2009. View at Publisher · View at Google Scholar
  40. K. R. Hegde and S. D. Varma, “Combination of glycemic and oxidative stress in lens: implications in augmentation of cataract formation in diabetes,” Free Radical Research, vol. 39, no. 5, pp. 513–517, 2005. View at Google Scholar
  41. X. H. Liu, X. W. Song, Y. Xu, and C. Zhang, “The inhibition of vitamin K3 on rabbit fibroblast proliferation in vitro,” Ophthalmologica, vol. 210, no. 3, pp. 180–182, 1996. View at Google Scholar · View at Scopus
  42. N. Sato and S. Watanabe, “Influence of extracellular matrix in gastric mucosal repair in vitro,” Biochemical and Biophysical Research Communications, vol. 202, no. 1, pp. 285–292, 1994. View at Publisher · View at Google Scholar
  43. R. J. Kirsner and H. Eaglestein, “The wound healing process,” Dermatologic Clinics, vol. 11, no. 4, pp. 629–640, 1993. View at Google Scholar
  44. J. G. Crowston, A. N. Akbar, P. H. Constable, N. L. Occleston, J. T. Daniels, and P. T. Khaw, “Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts,” Investigative Ophthalmology and Visual Science, vol. 39, no. 2, pp. 449–454, 1998. View at Google Scholar · View at Scopus
  45. F. Kawamura, N. Hirashima, T. Furuno, and M. Nakanishi, “Effects of 2-methyl-1,4-naphtoquinone (Menadione) on cellular signaling in RBL-2H3 cells,” Biological and Pharmaceutical Bulletin, vol. 29, no. 4, pp. 605–607, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. H. Morrison, B. Jernstrom, and M. Nordenskjold, “Induction of DNA damage by menadione (2-methyl-1,4-naphthoquinone) in primary cultures of rat hepatocytes,” Biochemical Pharmacology, vol. 33, no. 11, pp. 1763–1769, 1984. View at Publisher · View at Google Scholar · View at Scopus
  47. J. I. Beier, C. von Montfort, H. Sies, and L. O. Klotz, “Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: role of EGFR and protein tyrosine phosphatases,” FEBS Letters, vol. 580, no. 7, pp. 1859–1864, 2006. View at Publisher · View at Google Scholar · View at Scopus
  48. C. Lin, J. Kang, and R. Zheng, “Vitamin K3 triggers human leukemia cell death through hydrogen peroxide generation and histone hyperacetylation,” Pharmazie, vol. 60, no. 10, pp. 765–771, 2005. View at Google Scholar · View at Scopus
  49. S. Kuriyama, M. Hitomi, H. Yoshiji et al., “Vitamins K2, K3 and K5 exert in vivo antitumor effects on hepatocellular carcinoma by regulating the expression of G1 phase-related cell cycle molecules,” International Journal of Oncology, vol. 27, no. 2, pp. 505–511, 2005. View at Google Scholar · View at Scopus