Site-Specific Analysis of Inflammatory Markers in Discoid Lupus Erythematosus Skin

Figure 1

Comparisons of staining of T cell, B cell, and macrophage markers (CD3, CD4, CD8, CD20, CD68, CXCR3, CXCL10, and TIA-1) in the epidermis and dermoepidermal junction (DEJ) of DLE lesional skin (𝑁=23), psoriasis lesional skin (𝑁=11), and normal skin (𝑁=5). (a) The epidermis of psoriasis lesional skin contained higher levels of CD3⁺ and CD4⁺ T cells than DLE lesional skin. (b) The DEJ of DLE lesional skin expressed higher amounts of CD3⁺ T cells, CD8⁺ T cells, and CD68⁺ macrophages than psoriasis lesional skin and normal skin and higher amounts of CD4⁺ T cells, CD20⁺ B cells, and TIA-1 versus at least one of the control populations studied. *𝑃<0.01; **𝑃<0.001; ***𝑃<0.0001. (c) H&E and various immunostainings showed that the epidermis of psoriasis lesional skin contained higher levels of CD3⁺ and CD4⁺ T cells, while the DEJ of DLE lesional skin expressed higher amounts of CD3⁺ T cells, CD8⁺ T cells, and CD68⁺ macrophages. Magnification: 100x.