Site-Specific Analysis of Inflammatory Markers in Discoid Lupus Erythematosus Skin

Figure 2

Comparisons of staining of T cell, B cell, and macrophage markers (CD3, CD4, CD8, CD20, CD68, CXCR3, CXCL10, and TIA-1) in the perivascular area of DLE lesional skin (𝑁=23), psoriasis lesional skin (𝑁=11), and normal skin (𝑁=5). (a) The perivascular area of DLE lesional skin contained higher levels of CD3⁺ T cells, CD20⁺ B cells, and CD68⁺ macrophages, CXCR3, and TIA-1 compared with normal skin. *𝑃<0.01; **𝑃<0.001; ***𝑃<0.0001. (b) H&E and various immunostainings showed that the perivascular area of DLE lesional skin contained higher levels of CD3⁺ T cells, CD20⁺ B cells, and CD68⁺ macrophages, CXCR3, and TIA-1 compared with normal skin. No significant differences were discovered between DLE and psoriasis lesional skin. Magnification: 100x.