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The Scientific World Journal
Volume 2014, Article ID 926932, 12 pages
Review Article

Maternal Circulating Concentrations of Tumor Necrosis Factor-Alpha, Leptin, and Adiponectin in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

1Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China
2First Affiliated Hospital of Harbin Medical University, 199 Dazhi Street, Nangang District, Harbin, Heilongjiang 150001, China
3Second Affiliated Hospital of Harbin Medical University, 148 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China

Received 4 May 2014; Revised 4 July 2014; Accepted 18 July 2014; Published 19 August 2014

Academic Editor: José L. Bartha

Copyright © 2014 Jie Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications. Inflammation may play a role in the pathogenesis of GDM. We performed a systematic review and meta-analysis to determine whether maternal serum concentration of tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin were associated with GDM. A systematic search of PubMed and Medline was undertaken. In total, 27 trials were evaluated by meta-analyses using the software Review Manager 5.0. The results showed that maternal TNF-α () and leptin () concentrations were significantly higher in GDM patients versus controls. However, maternal adiponectin () concentration was significantly lower in GDM patients compared with controls. Subgroup analysis taking in consideration the effect of obesity on maternal adipokine levels showed that circulating levels of TNF-α and leptin remained elevated in GDM patients compared to their body mass index (BMI) matched controls, and adiponectin level remained depressed in GDM individuals. Our findings strengthen the clinical evidence that GDM is accompanied by exaggerated inflammatory responses.