Safety Evaluation of Multiple Strains of Lactobacillus plantarum and Pediococcus pentosaceus in Wistar Rats Based on the Ames Test and a 28-Day Feeding Study

Table 1

The specific growth rate* (SGR) (mean ± S.D) of rats that were fed with multiple LAB strains at different doses for 28 days.

Dose	Week 1		Week 2		Week 3		Week 4
	Male	Female	Male	Female	Male	Female	Male	Female
High	24.67 ± 9.26^a	24.67 ± 9.26^a	67.98 ± 7.06^a	58.85 ± 7.03^a	111.39 ± 11.98^a	75.08 ± 6.75^a	174.91 ± 23.06^a	110.29 ± 8.4^a
Normal	28.77 ± 1.53^a	27.61 ± 1.72^a	68.11 ± 5.26^a	58.08 ± 5.26^a	111.51 ± 8.1^a	77.54 ± 6.53^a	176.12 ± 13.44^a	114.71 ± 10.06^a
Control	30.36 ± 1.91^a	28.16 ± 4.36^a	69.96 ± 6.41^a	60.01 ± 5.89^a	110.64 ± 9.52^a	81.35 ± 5.42^a	175.57 ± 14.42^a	116.61 ± 10.77^a

Specific growth rate = (%), : rat weight on the defined feeding days; : rat weight on day 0.
(Duncan’s test). Statistical analysis was performed according to the procedures described in the Methods section. ^aA significant difference of the mean between male or female rats fed with control or a medium or high dose of LAB was not observed.