Safety Evaluation of Multiple Strains of Lactobacillus plantarum and Pediococcus pentosaceus in Wistar Rats Based on the Ames Test and a 28-Day Feeding Study

Table 2

Haematological findings in rats that were treated orally with multiple LAB strains for 28 days.

Parameters		Control	Multiplex LAB strains
			Normal dose	High dose
WBC (10^3/μL)	M	8.13 ± 0.84^a	8.21 ± 1.12^a	8.33 ± 0.92^a
	F	7.29 ± 2.66^a	9.5 ± 1.04^a	7.93 ± 1.66^a
RBC (10^6/μL)	M	6.84 ± 0.15^a	6.64 ± 0.17^a	6.8 ± 0.22^a
	F	6.83 ± 0.41^a	6.6 ± 0.31^a	6.75 ± 0.2^a
Haemoglobin (g/dL)	M	14.69 ± 0.25^a	14.69 ± 0.18^a	14.94 ± 0.19^b
	F	14.15 ± 1.06^a	14.4 ± 0.2^a	14.54 ± 0.29^a
Haematocrit (%)	M	44.38 ± 0.1^ab	42.66 ± 1.24^a	44.28 ± 1.6^b
	F	42.64 ± 1.06^a	41.8 ± 2.24^a	42.71 ± 1.95^a
MCV (fL)	M	64.33 ± 2.41^a	64.25 ± 0.97^a	65.18 ± 3.56^a
	F	62.4 ± 2.16^a	63.8 ± 5.77^a	63.29 ± 2.72^a
MCH (pg)	M	21.44 ± 0.71^a	22.13 ± 0.18^a	21.99 ± 0.72^a
	F	20.7 ± 1.05^a	21.9 ± 0.8^b	21.55 ± 0.54^ab
MCHC (%)	M	33.23 ± 0.57^a	34.43 ± 0.9^a	33.79 ± 1.4^a
	F	33.21 ± 1.88^a	34.5 ± 2.29^a	34.08 ± 1.08^a
Platelet (10^3/μL)	M	720 ± 53.84^a	769.5 ± 146.9^a	832.25 ± 154.2^a
	F	707.75 ± 281.54^a	774.3 ± 187.43^a	780.38 ± 91.37^a

All values are represented as the mean ± S.D. of Wistar rat ( = 7-8/sex/dose).
WBC: mean white blood cell; RBC: mean red blood cell; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; M: male; F: female.
^a,b compared with the control group by ANOVA followed by Dunnett’s test.