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The Scientific World Journal
Volume 2014, Article ID 947946, 11 pages
http://dx.doi.org/10.1155/2014/947946
Research Article

Characterization of Metabolites of Leonurine (SCM-198) in Rats after Oral Administration by Liquid Chromatography/Tandem Mass Spectrometry and NMR Spectrometry

1School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226001, China
2Department of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, China
3Department of Clinical Pharmacy, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, China
4Analytical and Testing Center, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, China

Received 25 August 2013; Accepted 31 December 2013; Published 24 February 2014

Academic Editors: J.-T. Cheng and M. W. Jann

Copyright © 2014 Qing Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [4 citations]

The following is the list of published articles that have cited the current article.

  • Ying Wang, Yang Cao, Xianfeng Gu, Qing Zhu, and Yi Zhun Zhu, “The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: Synthesis, activity and target identification,” Scientific Reports, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Mei Zeng, Lan Yang, Dan He, Yao Li, Mingxin Shi, and Jingqing Zhang, “Metabolic pathways and pharmacokinetics of natural medicines with low permeability,” Drug Metabolism Reviews, vol. 49, no. 4, pp. 464–476, 2017. View at Publisher · View at Google Scholar
  • Ying Wang, Qiuyan Zhang, Liangjie Zhong, Mingshen Lin, Xiaoling Luo, Siyu Liu, Peng Xu, Xinhua Liu, and Yi Zhun Zhu, “Apoptotic Protease Activating Factor-1 Inhibitor Mitigates Myocardial Ischemia Injury via Disturbing Procaspase-9 Recruitment by Apaf-1,” Oxidative Medicine and Cellular Longevity, vol. 2017, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • David R. Sell, Ina Nemet, Zhili Liang, and Vincent M. Monnier, “Evidence of glucuronidation of the glycation product LW-1: tentative structure and implications for the long-term complications of diabetes,” Glycoconjugate Journal, 2018. View at Publisher · View at Google Scholar